DNA2

Gene Symbol	DNA2
Entrez Gene	1763
Alt Symbol	DNA2L, hDNA2
Species	Human
Gene Type	protein-coding
Description	DNA replication helicase/nuclease 2
Other Description	DNA replication ATP-dependent helicase-like homolog|DNA replication ATP-dependent helicase/nuclease DNA2|DNA replication helicase 2 homolog|DNA2-like helicase
Swissprots	Q8N346 Q7Z6H9 Q6PI80 Q5TC49 P51530 Q2NKM1 Q5TC50 Q6P455
Accessions	P51530 AK307939 AK308333 AK308358 BC017003 BC028188 AAH28188 BC041115 AAH41115 BC053574 AAH53574 BC063664 AAH63664 BC073945 BC111740 AAI11741 D42046 BAA07647 DC404138 XM_006717680 XP_006717743 XM_011539416 XP_011537718 XM_011539417 XP_011537719 XM_011539418 XP_011537720 XM_011539419 XP_011537721 NM_001080449 NP_001073918 NR_102264
Function	Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double- strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)- dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. Accord
Subcellular Location	Nucleus. Mitochondrion. Note=Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465). {ECO:0000269|PubMed:18995831, ECO:0000269|PubMed:19487465}.
Top Pathways	DNA replication

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DNA2L (A-3) - sc-393323 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

DNA2L (H-86) - sc-366451 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

DNA2L (N-14) - sc-138770 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

DNA2L (S-12) - sc-138771 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

DNA2L (T-14) - sc-138772 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-DNA2 antibody - ab96488 from Abcam Prices $382.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DNA2 antibody - ab194939 from Abcam Prices $384.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNA2 antibody - ab197283 from Abcam Prices $376.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNA2 Antibody (aa337-366, AP) - LS-C256157 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNA2 Antibody (aa337-366, Biotin) - LS-C256159 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNA2 Antibody (aa337-366, FITC) - LS-C256160 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNA2 Antibody (aa337-366, APC) - LS-C256158 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNA2 Antibody (aa37-351) - LS-C311740 from LifeSpan Bioscience Prices $250.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DNA2 Antibody (aa337-366, PE) - LS-C256162 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNA2 Antibody (aa337-366, Azide-free, HRP) - LS-C256161 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNA2 Antibody (aa337-366) - LS-C320874 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNA2 Antibody (Internal) - LS-C345787 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DNA2 Antibody (aa330-358) IHC-plus™ - LS-B11099 from LifeSpan Bioscience Prices $395.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

DNA2 Antibody - NBP1-85006 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ANTI-DNA2 (CENTER) antibody produced in rabbit - SAB1305430 from Sigma-Aldrich Prices $326.00 Sizes 40 tst Host Rabbit Clonality Polyclonal

Anti-DNA2L antibody produced in rabbit - SAB2100603 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

DNA2L antibody - middle region (ARP36549_P050) - ARP36549_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DNA2 Antibody - middle region (ARP74491_P050) - ARP74491_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DNA2 Antibody - middle region (OAAB00188) - OAAB00188 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

DNA2-Antibody-Center - AP10182c from Abgent, a WuXi AppTec company Prices $95.00, $265.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

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