DNA2

Gene Symbol	DNA2
Entrez Gene	1763
Alt Symbol	DNA2L, hDNA2
Species	Human
Gene Type	protein-coding
Description	DNA replication helicase/nuclease 2
Other Description	DNA replication ATP-dependent helicase-like homolog|DNA replication ATP-dependent helicase/nuclease DNA2|DNA replication helicase 2 homolog|DNA2-like helicase
Swissprots	Q8N346 Q7Z6H9 Q6PI80 Q5TC49 P51530 Q2NKM1 Q5TC50 Q6P455
Accessions	P51530 AK307939 AK308333 AK308358 BC017003 BC028188 AAH28188 BC041115 AAH41115 BC053574 AAH53574 BC063664 AAH63664 BC073945 BC111740 AAI11741 D42046 BAA07647 DC404138 XM_006717680 XP_006717743 XM_011539416 XP_011537718 XM_011539417 XP_011537719 XM_011539418 XP_011537720 XM_011539419 XP_011537721 NM_001080449 NP_001073918 NR_102264
Function	Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double- strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)- dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. Accord
Subcellular Location	Nucleus. Mitochondrion. Note=Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465). {ECO:0000269|PubMed:18995831, ECO:0000269|PubMed:19487465}.
Top Pathways	DNA replication

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DNA2 peptide - ab42548 from Abcam Category Peptide

Human DNA2 peptide - ab42549 from Abcam Category Peptide

DNA2 Blocking Peptide - LS-E93 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNA2 Blocking Peptide - LS-E13091 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNA2-Antibody-Center-Blocking-peptide - BP10182c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DNA2L Blocking Peptide - 33R-4506 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DNA2 fusion protein - Ag17119 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DNA2 fusion protein - ag16206 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DNA2, His-tagged - DNA2-12048H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human DNA2-like helicase(DNA2) ,partial - CSB-YP006982HU CSB-EP006982HU CSB-BP006982HU CSB-MP006982HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human DNA2 HEK293T cell lysate - DNA2-197HCL from Creative Biomart Category Protein Source Human HEK293T cell line Species Human

DNA2 Recombinant Protein Antigen - NBP1-85006PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DNA2 Peptide, Human - M34GP04381H from Creative Peptides Category Peptide Source Synthetic. Species Human

DNA2-like helicase (DNA2), partial, Recombinant Protein - MBS1025954 from MyBioSource Category Protein Prices $1,685.00, $1,845.00, $1,990.00, $2,100.00, $2,300.00, $2,340.00, $2,625.00, $2,895.00, $3,325.00, $4,150.00 Sizes 50 µg (Baculovirus), 500 µg (E-Coli), 500 µg (Yeast), 100 µg (Baculovirus), 1 mg (E-Coli), 50 µg (Mammalian-Cell), 1 mg (Yeast), 100 µg (Mammalian-Cell), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

DNA2 Recombinant Protein Antigen - NBP2-57190PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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