DNA2

Gene Symbol DNA2
Entrez Gene 1763
Alt Symbol DNA2L, hDNA2
Species Human
Gene Type protein-coding
Description DNA replication helicase/nuclease 2
Other Description DNA replication ATP-dependent helicase-like homolog|DNA replication ATP-dependent helicase/nuclease DNA2|DNA replication helicase 2 homolog|DNA2-like helicase
Swissprots Q8N346 Q7Z6H9 Q6PI80 Q5TC49 P51530 Q2NKM1 Q5TC50 Q6P455
Accessions P51530 AK307939 AK308333 AK308358 BC017003 BC028188 AAH28188 BC041115 AAH41115 BC053574 AAH53574 BC063664 AAH63664 BC073945 BC111740 AAI11741 D42046 BAA07647 DC404138 XM_006717680 XP_006717743 XM_011539416 XP_011537718 XM_011539417 XP_011537719 XM_011539418 XP_011537720 XM_011539419 XP_011537721 NM_001080449 NP_001073918 NR_102264
Function Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double- strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)- dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. Accord
Subcellular Location Nucleus. Mitochondrion. Note=Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465). {ECO:0000269|PubMed:18995831, ECO:0000269|PubMed:19487465}.
Top Pathways DNA replication

DNA2 overexpression lysate - LY420707 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

DNA2 Overexpression Lysate (Native) - NBP2-08334 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: DNA2 Overexpression Lysate (Adult Normal) [NBP2-08334] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DNA2.

Panoply™ Human DNA2 Knockdown Stable Cell Line - CSC-DC004381 from Creative biogene

Category Cell Line
Species Human
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