| Gene Symbol |
DNA2
|
| Entrez Gene |
1763
|
| Alt Symbol |
DNA2L, hDNA2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DNA replication helicase/nuclease 2
|
| Other Description |
DNA replication ATP-dependent helicase-like homolog|DNA replication ATP-dependent helicase/nuclease DNA2|DNA replication helicase 2 homolog|DNA2-like helicase
|
| Swissprots |
Q8N346 Q7Z6H9 Q6PI80 Q5TC49 P51530 Q2NKM1 Q5TC50 Q6P455
|
| Accessions |
P51530 AK307939 AK308333 AK308358 BC017003 BC028188 AAH28188 BC041115 AAH41115 BC053574 AAH53574 BC063664 AAH63664 BC073945 BC111740 AAI11741 D42046 BAA07647 DC404138 XM_006717680 XP_006717743 XM_011539416 XP_011537718 XM_011539417 XP_011537719 XM_011539418 XP_011537720 XM_011539419 XP_011537721 NM_001080449 NP_001073918 NR_102264
|
| Function |
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double- strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)- dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. Accord
|
| Subcellular Location |
Nucleus. Mitochondrion. Note=Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465). {ECO:0000269|PubMed:18995831, ECO:0000269|PubMed:19487465}.
|
| Top Pathways |
DNA replication
|