HCRT

Gene Symbol HCRT
Entrez Gene 3060
Alt Symbol NRCLP1, OX, PPOX
Species Human
Gene Type protein-coding
Description hypocretin (orexin) neuropeptide precursor
Other Description orexin|prepro-orexin
Swissprots O43612
Accessions AAD24459 EAW60810 O43612 AF041240 AAC39600 BC111915 AAI11916 NM_001524 NP_001515
Function Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
Subcellular Location Rough endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250}.
Tissue Specificity Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Orexin-A (C-19) - sc-8070 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Orexin-A (N-18) - sc-26491 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Orexin-A (KK09) - sc-80263 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Orexin-A/B (A-14) - sc-33339 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Orexin-A/B (H-104) - sc-28935 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Orexin-B (C-19) - sc-8071 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Orexin A antibody - ab35337 from Abcam

Prices $370.00
Sizes 500 µl
Host Sheep
Clonality Polyclonal

Anti-Orexin A antibody - ab64565 from Abcam

Prices $370.00
Sizes 250 µl
Host Sheep
Clonality Polyclonal

Anti-Orexin A antibody [MM0500-8G22] - ab89886 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0500-8G22

Anti-Orexin antibody - ab199275 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human lung cancer tissue labeling Pan Orexin with ab199275 at 1/20 dilution.

Anti-Orexin B antibody - ab170999 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Orexin B antibody (ab170999) at 1 µg/ml + Rat testis cell lysate at 10 µg

Anti-Orexin B antibody [MM0501-5G21] - ab89888 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0501-5G21
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placental tissue section (4µm) labelling Orexin B with ab89888. Tissue was treated with 15µg/ml Protenase K for antigen retrieval and fixed with 4% PFA. A HRP-conjugated anti-mouse IgG was used as the secondary antibody (30 minutes at room temperature) followed by DAB color development.

Anti-HCRT / Orexin Antibody (N-Terminus) - LS-C37900 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HCRT / Orexin Antibody (N-Terminus) - LS-C37901 from LifeSpan Bioscience

Prices $495.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HCRT / Orexin Antibody (C-Terminus) - LS-C37907 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-HCRT / Orexin Antibody (N-Terminus) - LS-C37905 from LifeSpan Bioscience

Prices $495.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HCRT / Orexin Antibody (N-Terminus) - LS-C37904 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HCRT / Orexin Antibody (N-Terminus) - LS-C37903 from LifeSpan Bioscience

Prices $560.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HCRT / Orexin Antibody - LS-C37902 from LifeSpan Bioscience

Prices $475.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-HCRT / Orexin Antibody (N-Terminus) - LS-C37906 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HCRT / Orexin Antibody (C-Terminus) - LS-C37908 from LifeSpan Bioscience

Prices $560.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HCRT / Orexin Antibody (aa2-14) - LS-C122252 from LifeSpan Bioscience

Prices $435.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-HCRT / Orexin Antibody (aa12-33) - LS-C124312 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HCRT / Orexin Antibody (aa45-94) - LS-C170314 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HCRT / Orexin Antibody IHC-plus™ - LS-B31 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Sheep
Clonality Polyclonal
Anti-HCRT / Orexin antibody IHC of human brain, hypothalamus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B31 concentration 10 ug/ml.
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