| Gene Symbol |
HCRT
|
| Entrez Gene |
3060
|
| Alt Symbol |
NRCLP1, OX, PPOX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hypocretin (orexin) neuropeptide precursor
|
| Other Description |
orexin|prepro-orexin
|
| Swissprots |
O43612
|
| Accessions |
AAD24459 EAW60810 O43612 AF041240 AAC39600 BC111915 AAI11916 NM_001524 NP_001515
|
| Function |
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
|
| Subcellular Location |
Rough endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250}.
|
| Tissue Specificity |
Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
|