HCRT

Gene Symbol	HCRT
Entrez Gene	3060
Alt Symbol	NRCLP1, OX, PPOX
Species	Human
Gene Type	protein-coding
Description	hypocretin (orexin) neuropeptide precursor
Other Description	orexin|prepro-orexin
Swissprots	O43612
Accessions	AAD24459 EAW60810 O43612 AF041240 AAC39600 BC111915 AAI11916 NM_001524 NP_001515
Function	Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
Subcellular Location	Rough endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250}.
Tissue Specificity	Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HCRT / Orexin Antibody Blocking Peptide - LS-E21773 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Hypocretin-2-Gly-Human - SP3072b from Abgent, a WuXi AppTec company Category Peptide Prices $165.00 Sizes 1 mg Species Human

Hypocretin-2-Gly-Human - SP3072a from Abgent, a WuXi AppTec company Category Peptide Prices $125.00 Sizes 500 µg Species Human

Orexin-B-human - SP3071b from Abgent, a WuXi AppTec company Category Peptide Prices $195.00 Sizes 1 mg Species Human

Orexin-B-human - SP3071a from Abgent, a WuXi AppTec company Category Peptide Prices $125.00 Sizes 500 µg Species Human

Orexin B Peptide - 350309 from ABBIOTEC Category Peptide Prices $212.00 Sizes 1 mg

Orexin A Peptide - 350307 from ABBIOTEC Category Peptide Prices $590.00 Sizes 1 mg

Recombinant Orexin (OX) - RPA346Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Orexin (OX) - RPA346Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Orexin (OX) - RPA346Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Orexin-A, control peptide for AB3098 - AG774 from EMD Millipore Category Peptide Prices $195.00 Sizes 100 µg Source 18 amino acid peptide from the amino terminus of mouse Orexin-A.

Recombinant Orexin (OX) - RPA346Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Orexin(HCRT) - CSB-YP010230HU CSB-EP010230HU CSB-BP010230HU CSB-MP010230HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Orexin A, Peptide - MBS633704 from MyBioSource Category Peptide Prices $330.00 Sizes 500 µg Source Synthetic peptide

Orexin A, aa1-33, Cyclized, Peptide - MBS633831 from MyBioSource Category Peptide Prices $435.00 Sizes 1 mg

Orexin B, Peptide - MBS633875 from MyBioSource Category Peptide Prices $335.00 Sizes 1 mg Source Synthetic peptide Species Human

Orexin B, Peptide - MBS659042 from MyBioSource Category Peptide Prices $335.00 Sizes 1 mg Source Synthetic peptide Species Mouse

HCRT Peptide, Human - M34GP06880H from Creative Peptides Category Peptide Source Synthetic. Species Human

Orexin (HCRT), Recombinant Protein - MBS1175207 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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