HCRT

Gene Symbol HCRT
Entrez Gene 3060
Alt Symbol NRCLP1, OX, PPOX
Species Human
Gene Type protein-coding
Description hypocretin (orexin) neuropeptide precursor
Other Description orexin|prepro-orexin
Swissprots O43612
Accessions AAD24459 EAW60810 O43612 AF041240 AAC39600 BC111915 AAI11916 NM_001524 NP_001515
Function Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
Subcellular Location Rough endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250}.
Tissue Specificity Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Orexin-A CRISPR/Cas9 KO Plasmid (h) - sc-400357 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Orexin-A HDR Plasmid (h) - sc-400357-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Orexin-A Double Nickase Plasmid (h) - sc-400357-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Orexin-A Double Nickase Plasmid (h2) - sc-400357-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Orexin-A CRISPR Activation Plasmid (h) - sc-400357-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Orexin-A CRISPR Activation Plasmid (h2) - sc-400357-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Orexin-A Lentiviral Activation Particles (h) - sc-400357-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Orexin-A Lentiviral Activation Particles (h2) - sc-400357-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Orexin-A/B siRNA (h) - sc-42152 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Orexin-A/B shRNA Plasmid (h) - sc-42152-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Orexin-A/B shRNA (h) Lentiviral Particles - sc-42152-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN9929 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

HCRT siRNA (Human) - CRH2082 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HCRT - MBS8227805 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Orexin-A CRISPR/Cas9 KO Plasmid (h2) - sc-400357-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Orexin-A HDR Plasmid (h2) - sc-400357-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human HCRT (NM_001524.1) - SHH310885 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human HCRT(NM_001524.1) - SHH115895 from Creative biogene

Category siRNA
Species Reactivities Human

Human HCRT siRNA - orb262584 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HCRT shRNA Plasmid (Human) - CHH2082 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HCRT miRNA 3'UTR clone - MiUTR1H-04410 from Creative biogene

Species Reactivities Human
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