| Gene Symbol | IRAK1 |
|---|---|
| Entrez Gene | 3654 |
| Alt Symbol | IRAK, pelle |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin-1 receptor-associated kinase 1 |
| Other Description | IRAK-1|Pelle homolog |
| Swissprots | Q96C06 D3DWW4 D3DWW3 Q96RL2 P51617 Q7Z5V4 |
| Accessions | AAC08756 CCQ43144 EAW72760 EAW72761 EAW72762 EAW72763 EAW72764 EAW72765 P51617 AF346607 AAK62888 AM392624 CAL37502 AM393211 CAL38089 BC014963 AAH14963 BC054000 AAH54000 BE276817 DQ054788 AAY88246 EU831427 ACE87114 EU831520 ACE86439 L76191 AAC41949 XM_005274668 XP_005274725 XM_011531158 XP_011529460 NM_001025242 NP_001020413 NM_001025243 NP_001020414 NM_001569 NP_001560 |
| Function | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation a |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16690127}. Nucleus {ECO:0000269|PubMed:16690127}. Lipid droplet {ECO:0000250}. Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}. |
| Tissue Specificity | Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. {ECO:0000269|PubMed:11397809}. |
| Top Pathways | Toxoplasmosis, Epstein-Barr virus infection, Tuberculosis, Measles, Pertussis |
Human IRAK1 / IRAK ELISA Kit (Sandwich ELISA) - LS-F4780 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-IRAK1 / IRAK (Thr100) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1400 from LifeSpan Bioscience
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Human Phospho-IRAK1 / IRAK (Thr209) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1401 from LifeSpan Bioscience
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Human IRAK1 / IRAK ELISA Kit (Sandwich ELISA) - LS-F11834 from LifeSpan Bioscience
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Human IRAK ELISA Kit - abx054575 from Abbexa
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Human IRAK1 ELISA Kit - abx152054 from Abbexa
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Interleukin 1 Receptor Associated Kinase 1 (IRAK1), Human, ELISA Kit - SEB514Hu from ARP American Research Products
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Interleukin-1 receptor-associated kinase 1 (IRAK1), Human, ELISA Kit - CSB-E09933h from ARP American Research Products
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Interleukin-1 receptor-associated kinase 1, IRAK1, Human, ELISA Kit - E1514h from ARP American Research Products
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IRAK1 (Human) IP-WB Antibody Pair - H00003654-PW1 from Acris Antibodies
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IRAK1 (Human) IP-WB Antibody Pair - H00003654-PW2 from Acris Antibodies
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IRAK1 (Human) IP-WB Antibody Pair - H00003654-PW3 from Acris Antibodies
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Human IRAK ELISA Kit - HI0411 from NeoScientific
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Anserine IRAK ELISA Kit - AI0411 from NeoScientific
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IRAK1 (Phospho-Thr100) Colorimetric Cell-Based ELISA Kit - CBP1424 from Assay Biotechnology
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IRAK1 (Phospho-Thr209) Colorimetric Cell-Based ELISA Kit - CBP1425 from Assay Biotechnology
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Interleukin 1 Receptor Associated Kinase (IRAK), ELISA Kit - MBS264220 from MyBioSource
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Interleukin 1 Receptor Associated Kinase (IRAK), ELISA Kit - MBS269345 from MyBioSource
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Interleukin 1 Receptor Associated Kinase (IRAK), ELISA Kit - MBS2601649 from MyBioSource
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Interleukin 1 Receptor Associated Kinase (IRAK), ELISA Kit - MBS265142 from MyBioSource
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Interleukin 1 Receptor Associated Kinase (IRAK), ELISA Kit - MBS265931 from MyBioSource
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Interleukin 1 Receptor Associated Kinase (IRAK), ELISA Kit - MBS261341 from MyBioSource
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Interleukin 1 Receptor Associated Kinase (IRAK), ELISA Kit - MBS268773 from MyBioSource
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Interleukin 1 Receptor Associated Kinase (IRAK), ELISA Kit - MBS260857 from MyBioSource
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Interleukin 1 Receptor Associated Kinase 1 (IRAK1), ELISA Kit - MBS2023087 from MyBioSource
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