IRAK1

Gene Symbol	IRAK1
Entrez Gene	3654
Alt Symbol	IRAK, pelle
Species	Human
Gene Type	protein-coding
Description	interleukin-1 receptor-associated kinase 1
Other Description	IRAK-1|Pelle homolog
Swissprots	Q96C06 D3DWW4 D3DWW3 Q96RL2 P51617 Q7Z5V4
Accessions	AAC08756 CCQ43144 EAW72760 EAW72761 EAW72762 EAW72763 EAW72764 EAW72765 P51617 AF346607 AAK62888 AM392624 CAL37502 AM393211 CAL38089 BC014963 AAH14963 BC054000 AAH54000 BE276817 DQ054788 AAY88246 EU831427 ACE87114 EU831520 ACE86439 L76191 AAC41949 XM_005274668 XP_005274725 XM_011531158 XP_011529460 NM_001025242 NP_001020413 NM_001025243 NP_001020414 NM_001569 NP_001560
Function	Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation a
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16690127}. Nucleus {ECO:0000269|PubMed:16690127}. Lipid droplet {ECO:0000250}. Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. {ECO:0000269|PubMed:11397809}.
Top Pathways	Toxoplasmosis, Epstein-Barr virus infection, Tuberculosis, Measles, Pertussis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IRAK1 293T Cell Transient Overexpression Lysate(Denatured) - H00003654-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

IRAK1 overexpression lysate - LY422494 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

IRAK1 overexpression lysate - LY422495 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

IRAK1 overexpression lysate - LY425491 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

IRAK1 293 Cell Lysate - 400597 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

IRAK1 293 Cell Lysate - 409738 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

IRAK1 Overexpression Lysate (Denatured) - H00003654-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

IRAK1 Overexpression Lysate (Native) - NBL1-12025 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

IRAK1 Overexpression Lysate (Native) - NBL1-12026 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

IRAK-1 (h): 293T Lysate - sc-116528 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

IRAK-1 (h4): 293T Lysate - sc-177400 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

IRAK-1 (h5): 293T Lysate - sc-177399 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

IRAK1 Over-expression Lysate Product - GWB-8D1092 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

IRAK1 Over-expression Lysate Product - GWB-8A80B7 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

IRAK1 Overexpression Lysate (Native) - NBP2-11046 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

IRAK1 Overexpression Lysate (Native) - NBP2-11224 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

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