IRAK1

Gene Symbol	IRAK1
Entrez Gene	3654
Alt Symbol	IRAK, pelle
Species	Human
Gene Type	protein-coding
Description	interleukin-1 receptor-associated kinase 1
Other Description	IRAK-1|Pelle homolog
Swissprots	Q96C06 D3DWW4 D3DWW3 Q96RL2 P51617 Q7Z5V4
Accessions	AAC08756 CCQ43144 EAW72760 EAW72761 EAW72762 EAW72763 EAW72764 EAW72765 P51617 AF346607 AAK62888 AM392624 CAL37502 AM393211 CAL38089 BC014963 AAH14963 BC054000 AAH54000 BE276817 DQ054788 AAY88246 EU831427 ACE87114 EU831520 ACE86439 L76191 AAC41949 XM_005274668 XP_005274725 XM_011531158 XP_011529460 NM_001025242 NP_001020413 NM_001025243 NP_001020414 NM_001569 NP_001560
Function	Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation a
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16690127}. Nucleus {ECO:0000269|PubMed:16690127}. Lipid droplet {ECO:0000250}. Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. {ECO:0000269|PubMed:11397809}.
Top Pathways	Toxoplasmosis, Epstein-Barr virus infection, Tuberculosis, Measles, Pertussis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® IRAK1 siRNA I - 6253 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® IRAK1 siRNA II - 6228 from Cell Signaling Technology Category siRNA

IRAK-1 CRISPR/Cas9 KO Plasmid (h) - sc-400264 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-1 HDR Plasmid (h) - sc-400264-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-1 Double Nickase Plasmid (h) - sc-400264-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-1 Double Nickase Plasmid (h2) - sc-400264-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-1 CRISPR Activation Plasmid (h) - sc-400264-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-1 CRISPR Activation Plasmid (h2) - sc-400264-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-1 Lentiviral Activation Particles (h) - sc-400264-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-1 Lentiviral Activation Particles (h2) - sc-400264-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-1 siRNA (h) - sc-35704 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRAK-1 shRNA Plasmid (h) - sc-35704-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRAK-1 shRNA (h) Lentiviral Particles - sc-35704-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRAK1 RNAi - H00003654-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

IRAK1 RNAi - H00003654-R09 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU093291 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0973 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0975 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0974 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2001 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1114 from Sigma-Aldrich Category ZFN Kit Prices $6,000.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1115 from Sigma-Aldrich Category ZFN Kit Prices $6,000.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2001 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00042 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00042

IRAK1 siRNA (Human) - CRH2448 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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