IRAK1

Gene Symbol	IRAK1
Entrez Gene	3654
Alt Symbol	IRAK, pelle
Species	Human
Gene Type	protein-coding
Description	interleukin-1 receptor-associated kinase 1
Other Description	IRAK-1|Pelle homolog
Swissprots	Q96C06 D3DWW4 D3DWW3 Q96RL2 P51617 Q7Z5V4
Accessions	AAC08756 CCQ43144 EAW72760 EAW72761 EAW72762 EAW72763 EAW72764 EAW72765 P51617 AF346607 AAK62888 AM392624 CAL37502 AM393211 CAL38089 BC014963 AAH14963 BC054000 AAH54000 BE276817 DQ054788 AAY88246 EU831427 ACE87114 EU831520 ACE86439 L76191 AAC41949 XM_005274668 XP_005274725 XM_011531158 XP_011529460 NM_001025242 NP_001020413 NM_001025243 NP_001020414 NM_001569 NP_001560
Function	Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation a
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16690127}. Nucleus {ECO:0000269|PubMed:16690127}. Lipid droplet {ECO:0000250}. Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. {ECO:0000269|PubMed:11397809}.
Top Pathways	Toxoplasmosis, Epstein-Barr virus infection, Tuberculosis, Measles, Pertussis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IRAK (phospho T387) peptide - ab174118 from Abcam Category Peptide Species Human

Human IRAK full length protein - ab114271 from Abcam Category Protein Source Wheat germ Species Human

Human IRAK peptide - ab99364 from Abcam Category Peptide

Human IRAK peptide - ab174119 from Abcam Category Peptide

Human IRAK protein fragment - ab114272 from Abcam Category Protein Source Wheat germ Species Human

Human IRAK protein fragment - ab125533 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

IRAK peptide - ab6230 from Abcam Category Peptide

IRAK1 / IRAK Antibody Blocking Peptide - LS-E3283 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IRAK1 / IRAK Antibody Blocking Peptide - LS-E9272 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IRAK1 / IRAK Antibody Blocking Peptide - LS-E29830 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human IRAK1 Protein - H00003654-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human IRAK1 Protein - H00003654-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IRAK1 Peptide - P2804 from Novus Biologicals Category Peptide Species Human

IRAK1 Peptide - P1341 from Novus Biologicals Category Peptide Species Human

hIRAK1-S376-Abtibody-Blocking-peptide - BP10960a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-IRAK1S376-Antibody-Blocking-peptide - BP3139a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

IRAK-Antibody-C-term-Blocking-peptide - BP7802b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IRAK Recombinant Protein - GTX48182-PRO from GeneTex Category Protein Prices $299.00 Sizes 50 μg Source E. coli Species Human

IRAK peptide - GTX26230 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Human IRAK1 Protein - abx067406 from Abbexa Category Protein Source E.coli Species Human

IRAK1 (phospho-Thr209) Blocking Peptide - abx062799 from Abbexa Category Peptide Species Human, Mouse

IRAK1 - H00003654-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

IRAK1 - H00003654-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

IRAK1 - H00003654-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

IRAK1 - P5565 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

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