| Gene Symbol |
MCM2
|
| Entrez Gene |
4171
|
| Alt Symbol |
BM28, CCNL1, CDCL1, D3S3194, MITOTIN, cdc19
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
minichromosome maintenance complex component 2
|
| Other Description |
DNA replication licensing factor MCM2|MCM2 minichromosome maintenance deficient 2, mitotin|cell devision cycle-like 1|cyclin-like 1|minichromosome maintenance deficient 2 (mitotin)|minichromosome maintenance protein 2 homolog|nuclear protein BM28
|
| Swissprots |
P49736 Q15023 Q96AE1 Q14577 Q9BRM7 Q969W7 Q8N2V1
|
| Accessions |
AAT70723 CAR95152 CBX85462 CCD32687 EAW79339 P49736 AK128291 BAG54656 AK299934 BAG61767 AK304204 BAH14132 AK309335 BC000300 AAH00300 BC006165 AAH06165 BC007670 AAH07670 BC007938 AAH07938 BC014272 AAH14272 BC017258 AAH17258 BC017490 AAH17490 BC030131 AAH30131 BM153020 BT009733 AAP88735 BT009734 AAP88736 D21063 BAA04642 D83987 BAA12177 DB100427 X67334 CAA47749 NM_004526 NP_004517 NR_073375
|
| Function |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. {ECO:0000269|PubMed:8175912}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:8175912}.
|
| Top Pathways |
DNA replication, Cell cycle
|