Gene Symbol | SFRP5 |
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Entrez Gene | 6425 |
Alt Symbol | SARP3 |
Species | Human |
Gene Type | protein-coding |
Description | secreted frizzled-related protein 5 |
Other Description | FRP-1b|SARP-3|frizzled-related protein 1b|sFRP-5|secreted apoptosis related protein 3|secreted apoptosis-related protein 3 |
Swissprots | Q86TH7 Q5T4F7 O14780 |
Accessions | EAW49894 Q5T4F7 AF017988 AAB70794 AF117758 AAD25052 BC050435 AAH50435 NM_003015 NP_003006 |
Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina. |
Subcellular Location | Secreted {ECO:0000250}. |
Tissue Specificity | Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle. {ECO:0000269|PubMed:10072424, ECO:0000269|PubMed:9391078, ECO:0000269|PubMed:9642118}. |
Top Pathways | Wnt signaling pathway |
SARP3 (H-6) - sc-374397 from Santa Cruz Biotechnology
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SARP3 (E-19) - sc-14331 from Santa Cruz Biotechnology
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SARP3 (N-15) - sc-14330 from Santa Cruz Biotechnology
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Anti-SFRP5 antibody - ab198206 from Abcam
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Anti-SFRP5 antibody - C-terminal - ab157149 from Abcam
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Anti-SFRP5 Antibody (aa25-38) - LS-C40594 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (aa189-219, AP) - LS-C269121 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (aa189-219, APC) - LS-C269122 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (aa189-219, Biotin) - LS-C269123 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (aa189-219, FITC) - LS-C269124 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (aa189-219, PE) - LS-C269126 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (aa189-219, Azide-free, HRP) - LS-C269125 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (Internal, AP) - LS-C282685 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (Internal, APC) - LS-C282686 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (Internal, Biotin) - LS-C282687 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (Internal, FITC) - LS-C282689 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (Internal, Azide-free, HRP) - LS-C282691 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (Internal, PE) - LS-C282692 from LifeSpan Bioscience
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Anti-SFRP5 Antibody IHC-plus⢠- LS-B307 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (aa181-303, Biotin) - LS-C297735 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (aa48-165, Biotin) - LS-C300423 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (aa48-161, Biotin) - LS-C300424 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (aa181-303, FITC) - LS-C302013 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (aa48-165, FITC) - LS-C303306 from LifeSpan Bioscience
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Anti-SFRP5 Antibody (aa48-161, FITC) - LS-C303307 from LifeSpan Bioscience
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