Gene Symbol | SFRP5 |
---|---|
Entrez Gene | 6425 |
Alt Symbol | SARP3 |
Species | Human |
Gene Type | protein-coding |
Description | secreted frizzled-related protein 5 |
Other Description | FRP-1b|SARP-3|frizzled-related protein 1b|sFRP-5|secreted apoptosis related protein 3|secreted apoptosis-related protein 3 |
Swissprots | Q86TH7 Q5T4F7 O14780 |
Accessions | EAW49894 Q5T4F7 AF017988 AAB70794 AF117758 AAD25052 BC050435 AAH50435 NM_003015 NP_003006 |
Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina. |
Subcellular Location | Secreted {ECO:0000250}. |
Tissue Specificity | Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle. {ECO:0000269|PubMed:10072424, ECO:0000269|PubMed:9391078, ECO:0000269|PubMed:9642118}. |
Top Pathways | Wnt signaling pathway |