Gene Symbol | SFRP5 |
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Entrez Gene | 6425 |
Alt Symbol | SARP3 |
Species | Human |
Gene Type | protein-coding |
Description | secreted frizzled-related protein 5 |
Other Description | FRP-1b|SARP-3|frizzled-related protein 1b|sFRP-5|secreted apoptosis related protein 3|secreted apoptosis-related protein 3 |
Swissprots | Q86TH7 Q5T4F7 O14780 |
Accessions | EAW49894 Q5T4F7 AF017988 AAB70794 AF117758 AAD25052 BC050435 AAH50435 NM_003015 NP_003006 |
Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina. |
Subcellular Location | Secreted {ECO:0000250}. |
Tissue Specificity | Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle. {ECO:0000269|PubMed:10072424, ECO:0000269|PubMed:9391078, ECO:0000269|PubMed:9642118}. |
Top Pathways | Wnt signaling pathway |
Human SFRP5 full length protein - ab202176 from Abcam
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Human SFRP5 peptide - ab90997 from Abcam
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SFRP5 Antibody Blocking Peptide - LS-E2076 from LifeSpan Bioscience
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SFRP5 Antibody Blocking Peptide - LS-E8588 from LifeSpan Bioscience
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SFRP5-Antibody-Center-Blocking-peptide - BP12966c from Abgent, a WuXi AppTec company
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SFRP5-Antibody-Center-Blocking-Peptide - BP6991c from Abgent, a WuXi AppTec company
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Recombinant Human sFRP-5, CF - 6266-SF-050 from R&D Systems
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SFRP5 protein (His tag) - 80R-4100 from Fitzgerald
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Human SFRP5 Protein - abx068999 from Abbexa
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Human SFRP5 Protein - abx068996 from Abbexa
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SFRP5 (30-317, His-tag) - AR51786PU-N from Acris Antibodies
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SFRP5 (30-317, His-tag) - AR51786PU-S from Acris Antibodies
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Secreted Frizzled Related Protein 5 (SFRP5), Human - 20-8586 from ARP American Research Products
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Secreted Frizzled Related Protein 5 (SFRP5), Human - 20-8587 from ARP American Research Products
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SFRP5 fusion protein - Ag5715 from Proteintech Group
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SFRP5 fusion protein - ag5555 from Proteintech Group
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Recombinant Human SFRP5, His-tagged - SFRP5-2619H from Creative Biomart
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Recombinant Secreted Frizzled Related Protein 5 (SFRP5) - RPC842Hu01 from Uscn Life Science Inc.
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Recombinant Secreted Frizzled Related Protein 5 (SFRP5) - RPC842Hu02 from Uscn Life Science Inc.
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Recombinant Secreted Frizzled Related Protein 5 (SFRP5) - RPC842Mu01 from Uscn Life Science Inc.
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Recombinant Secreted Frizzled Related Protein 5 (SFRP5) - RPC842Mu02 from Uscn Life Science Inc.
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Recombinant Secreted Frizzled Related Protein 5 (SFRP5) - RPC842Ra01 from Uscn Life Science Inc.
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Recombinant Secreted Frizzled Related Protein 5 (SFRP5) - RPC842Hu01 from Cloud-clone
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Recombinant Secreted Frizzled Related Protein 5 (SFRP5) - RPC842Hu02 from Cloud-clone
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Recombinant Human Secreted frizzled-related protein 5(SFRP5) - CSB-YP021141HU CSB-EP021141HU CSB-BP021141HU CSB-MP021141HU from Cusabio
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