| Gene Symbol |
SFRP5
|
| Entrez Gene |
6425
|
| Alt Symbol |
SARP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
secreted frizzled-related protein 5
|
| Other Description |
FRP-1b|SARP-3|frizzled-related protein 1b|sFRP-5|secreted apoptosis related protein 3|secreted apoptosis-related protein 3
|
| Swissprots |
Q86TH7 Q5T4F7 O14780
|
| Accessions |
EAW49894 Q5T4F7 AF017988 AAB70794 AF117758 AAD25052 BC050435 AAH50435 NM_003015 NP_003006
|
| Function |
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.
|
| Subcellular Location |
Secreted {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle. {ECO:0000269|PubMed:10072424, ECO:0000269|PubMed:9391078, ECO:0000269|PubMed:9642118}.
|
| Top Pathways |
Wnt signaling pathway
|
![Western Blot: SFRP5 Overexpression Lysate (Adult Normal) [NBP2-08048] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SFRP5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4012_SFRP5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08048-img0001.jpg)