| Gene Symbol |
NKX2-1
|
| Entrez Gene |
7080
|
| Alt Symbol |
BCH, BHC, NK-2, NKX2.1, NKX2A, T/EBP, TEBP, TITF1, TTF-1, TTF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NK2 homeobox 1
|
| Other Description |
NK-2 homolog A|homeobox protein NK-2 homolog A|homeobox protein Nkx-2.1|thyroid nuclear factor 1|thyroid transcription factor 1|thyroid-specific enhancer-binding protein
|
| Swissprots |
P43699 O14954 Q9BRJ8 Q7KZF6 O14955 D3DSA3
|
| Accessions |
AAA83233 AAC12924 AAC50125 BAA23527 BAB56137 EAW65856 EAW65857 EAW65858 EAW65859 P43699 BC006221 AAH06221 BE796718 BM970287 BM970838 BT009773 AAP88775 D50740 BAA23529 D50741 BAA23528 DQ892964 ABM83890 DQ896211 ABM87210 U19756 AAA86099 U33749 AAB52381 U43203 AAA89066 X82850 CAA58053 NM_001079668 NP_001073136 NM_003317 NP_003308
|
| Function |
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). {ECO:0000250|UniProtKB:P23441, ECO:0000250|UniProtKB:P50220}.
|
| Subcellular Location |
Nucleus {ECO:0000250|UniProtKB:P50220}.
|
| Tissue Specificity |
Thyroid and lung.
|