NKX2-1

Gene Symbol NKX2-1
Entrez Gene 7080
Alt Symbol BCH, BHC, NK-2, NKX2.1, NKX2A, T/EBP, TEBP, TITF1, TTF-1, TTF1
Species Human
Gene Type protein-coding
Description NK2 homeobox 1
Other Description NK-2 homolog A|homeobox protein NK-2 homolog A|homeobox protein Nkx-2.1|thyroid nuclear factor 1|thyroid transcription factor 1|thyroid-specific enhancer-binding protein
Swissprots P43699 O14954 Q9BRJ8 Q7KZF6 O14955 D3DSA3
Accessions AAA83233 AAC12924 AAC50125 BAA23527 BAB56137 EAW65856 EAW65857 EAW65858 EAW65859 P43699 BC006221 AAH06221 BE796718 BM970287 BM970838 BT009773 AAP88775 D50740 BAA23529 D50741 BAA23528 DQ892964 ABM83890 DQ896211 ABM87210 U19756 AAA86099 U33749 AAB52381 U43203 AAA89066 X82850 CAA58053 NM_001079668 NP_001073136 NM_003317 NP_003308
Function Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). {ECO:0000250|UniProtKB:P23441, ECO:0000250|UniProtKB:P50220}.
Subcellular Location Nucleus {ECO:0000250|UniProtKB:P50220}.
Tissue Specificity Thyroid and lung.

TTF-1 CRISPR/Cas9 KO Plasmid (h) - sc-400458 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TTF-1 HDR Plasmid (h) - sc-400458-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TTF-1 Double Nickase Plasmid (h) - sc-400458-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TTF-1 Double Nickase Plasmid (h2) - sc-400458-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TTF-1 CRISPR Activation Plasmid (h) - sc-400458-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TTF-1 CRISPR Activation Plasmid (h2) - sc-400458-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TTF-1 Lentiviral Activation Particles (h) - sc-400458-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TTF-1 Lentiviral Activation Particles (h2) - sc-400458-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TTF-1 siRNA (h) - sc-36756 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TTF-1 shRNA Plasmid (h) - sc-36756-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TTF-1 shRNA (h) Lentiviral Particles - sc-36756-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TTF1 / NKX2.1 RNAi - H00007080-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
TTF1 / NKX2.1 RNAi [H00007080-R01] - Position of the Chimera RNAi.

CompoZr® Knockout ZFN Kit - CKOZFN15329 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15329 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07411 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07411

NKX2-1 siRNA (Human) - CRH4849 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TITF1(NM_003317.3) - SHL102828 from Creative biogene

Category siRNA
Species Reactivities Human

NKX2-1 shRNA Plasmid (Human) - CHH4849 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NKX2-1 miRNA 3'UTR clone - MiUTR3H-03531 from Creative biogene

Species Reactivities Human

NKX2-1 miRNA 3'UTR clone - MiUTR3H-03532 from Creative biogene

Species Reactivities Human
Search more