| Gene Symbol |
CLK3
|
| Entrez Gene |
1198
|
| Alt Symbol |
PHCLK3, PHCLK3/152
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CDC-like kinase 3
|
| Other Description |
dual specificity protein kinase CLK3
|
| Swissprots |
Q9BUJ7 D3DW59 Q53Y48 Q9BRS3 P49761
|
| Accessions |
EAW99320 EAW99321 EAW99322 EAW99323 EAW99324 EAW99325 P49761 AB209535 BAD92772 AK026511 AK091692 BAG52400 AK095335 AK096115 BAG53214 AK097982 BAG53559 AK122860 BAG53765 AK225680 AK291983 BAF84672 AK293769 BAG57185 AK301689 BAG63161 AL833165 BC002555 AAH02555 BC006103 AAH06103 BC009857 BC019881 AAH19881 BI459843 BM678884 BQ183959 BT006993 AAP35639 CR933693 JF432199 ADZ15416 L29217 AAA61484 L29220 AAA61483 XM_005254151 XP_005254208 XM_005254153 XP_005254210 XM_006720384 XP_006720447 XM_011521205 XP_011519507 XM_011521206 XP_011519508 XM_011521207 XP_011519509 XM_011521208 XP_011519510 XM_011521209 XP_011519511 XM_011521210 XP_011519512 XR_931746 NM_001130028 NP_001123500 NM_003992 NP_003983 NM_001292
|
| Function |
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:9637771}.
|
| Subcellular Location |
Isoform 1: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.
|
| Tissue Specificity |
Endothelial cells. {ECO:0000269|PubMed:19168442}.
|