CLK3

Gene Symbol CLK3
Entrez Gene 1198
Alt Symbol PHCLK3, PHCLK3/152
Species Human
Gene Type protein-coding
Description CDC-like kinase 3
Other Description dual specificity protein kinase CLK3
Swissprots Q9BUJ7 D3DW59 Q53Y48 Q9BRS3 P49761
Accessions EAW99320 EAW99321 EAW99322 EAW99323 EAW99324 EAW99325 P49761 AB209535 BAD92772 AK026511 AK091692 BAG52400 AK095335 AK096115 BAG53214 AK097982 BAG53559 AK122860 BAG53765 AK225680 AK291983 BAF84672 AK293769 BAG57185 AK301689 BAG63161 AL833165 BC002555 AAH02555 BC006103 AAH06103 BC009857 BC019881 AAH19881 BI459843 BM678884 BQ183959 BT006993 AAP35639 CR933693 JF432199 ADZ15416 L29217 AAA61484 L29220 AAA61483 XM_005254151 XP_005254208 XM_005254153 XP_005254210 XM_006720384 XP_006720447 XM_011521205 XP_011519507 XM_011521206 XP_011519508 XM_011521207 XP_011519509 XM_011521208 XP_011519510 XM_011521209 XP_011519511 XM_011521210 XP_011519512 XR_931746 NM_001130028 NP_001123500 NM_003992 NP_003983 NM_001292
Function Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:9637771}.
Subcellular Location Isoform 1: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.
Tissue Specificity Endothelial cells. {ECO:0000269|PubMed:19168442}.

CLK3-Over-expression-Lysate - LY10945a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag CLK3 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CLK3 gene

CLK3 293T Cell Transient Overexpression Lysate(Denatured) - H00001198-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

CLK3 overexpression lysate - LY418305 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

CLK3 (h2): 293T Lysate - sc-158385 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

CLK3 (h3): 293T Lysate - sc-158386 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Human CLK3 Insect Cell Lysate (WB positive control) - 10716-H09BL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

CLK3 Overexpression Lysate (Denatured) - H00001198-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Human CLK3 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb174936 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Panoply™ Human CLK3 Knockdown Stable Cell Line - CSC-DC003294 from Creative biogene

Category Cell Line
Species Human

Human CLK3 Knockout Cell Line-HeLa - CSC-RT0789 from Creative biogene

Category Cell Line
Species Human

CLK3 KO Cell Lysate-HeLa - CLKO-0292 from Creative biogene

Category Cell Lysate
Search more