MLYCD

Gene Symbol MLYCD
Entrez Gene 23417
Alt Symbol MCD
Species Human
Gene Type protein-coding
Description malonyl-CoA decarboxylase
Other Description malonyl coenzyme A decarboxylase|malonyl-CoA decarboxylase, mitochondrial
Swissprots Q9UNU5 Q9Y3F2 O95822
Accessions EAW95513 O95822 AF090834 AAD48994 AF097832 AAD16177 AF153679 AAD34631 AK094095 BC000286 AAH00286 BC052592 AAH52592 NM_012213 NP_036345
Function Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. {ECO:0000269|PubMed:10455107, ECO:0000269|PubMed:15003260, ECO:0000269|PubMed:18314420, ECO:0000269|PubMed:23482565}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10417274}. Mitochondrion matrix {ECO:0000269|PubMed:10417274}. Peroxisome {ECO:0000269|PubMed:10417274}. Peroxisome matrix {ECO:0000250}. Note=Enzymatically active in all three subcellular compartments. {ECO:0000250}.
Tissue Specificity Expressed in fibroblasts and hepatoblastoma cells (at protein level). Expressed strongly in heart, liver, skeletal muscle, kidney and pancreas. Expressed in myotubes. Expressed weakly in brain, placenta, spleen, thymus, testis, ovary and small intestine. {ECO:0000269|PubMed:10455107, ECO:0000269|PubMed:18314420}.
Top Pathways Peroxisome, AMPK signaling pathway, beta-Alanine metabolism, Propanoate metabolism

Anti-MLYCD antibody - ab95945 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MLYCD antibody (ab95945) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-MLYCD antibody - ab69675 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-MLYCD / MCD Antibody - LS-C310990 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MLYCD / MCD Antibody - LS-C309019 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-MLYCD / MCD Antibody (aa90-304) - LS-C186124 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded H661 xenograft using MCD antibody at 1:500 dilution.

MLYCD Antibody - NBP1-32797 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MLYCD Antibody - NBP1-83247 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MLYCD Antibody [NBP1-83247] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-347

MLYCD Antibody - H00023417-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: MLYCD Antibody [H00023417-B01P] - Analysis of MLYCD expression in transfected 293T cell line by MLYCD polyclonal antibody. Lane 1: MLYCD transfected lysate(54.23 KDa). Lane 2: Non-transfected lysate.

MLYCD Antibody - H00023417-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: MLYCD Antibody [H00023417-D01P] - Analysis of MLYCD expression in transfected 293T cell line by MLYCD polyclonal antibody.Lane 1: MLYCD transfected lysate(55.00 KDa).Lane 2: Non-transfected lysate.

Anti-MLYCD antibody produced in rabbit - SAB1410421 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MLYCD: <B>Cat. No. SAB1410421</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~55 kDa using MLYCD transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-MLYCD antibody produced in rabbit - SAB2702043 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MLYCD: <B>Cat. No. SAB2702043</B>: Immunohistochemical analysis of paraffin-embedded H661 xenograft, using MCD antibody at a 1:500 dilution.

Anti-MLYCD antibody produced in rabbit - HPA031625 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MLYCD: <B>Cat. No. HPA031625</B>: Immunohistochemical staining of human duodenum shows moderate cytoplasmic positivity in glandular cells.

Anti-MLYCD antibody produced in mouse - SAB1407210 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MLYCD: <B>Cat. No. SAB1407210</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~54.2 kDa using MLYCD transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

MLYCD antibody - 70R-18540 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

MLYCD antibody (OAGA00820) - OAGA00820 from Aviva Systems Biology

Prices $340.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MCD antibody - 70R-13334 from Fitzgerald

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MLYCD antibody - 15265-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded H-kidney(glomerulus) using 15265-1-AP(MLYCD Antibody) at Dilution 1:50 (under 10x lens)

MLYCD antibody - H00023417-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot analysis of MLYCD expression in transfected 293T cell line (H00023417-T01) by MLYCD MaxPab polyclonal antibody. Lane 1: MLYCD transfected lysate(54.23 KDa). Lane 2: Non-transfected lysate.

MLYCD antibody - H00023417-D01P from Acris Antibodies

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Rabbit Anti-Human MCD, Internal - 107-10891 from RayBiotech

Host Rabbit

MLYCD antibody - 15265-1-AP from Proteintech Group

Prices $279.00
Sizes con: 29 μg/150μl
Host Rabbit
Clonality Polyclonal
human testis tissue were subjected to SDS PAGE followed by western blot with 15265-1-AP(MLYCD antibody) at dilution of 1:400

malonyl-CoA decarboxylase , Polyclonal Antibody - MBS712476 from MyBioSource

Prices $230.00, $500.00
Sizes 50 µl, 150 µl
Host Rabbit
Clonality Polyclonal

MCD antibody - 22115 from Signalway Antibody

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate)A: Hep G2 7.5% SDS PAGEPrimary antibody diluted at 1: 1000

MCD - MBS275495 from MyBioSource

Prices $360.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
MCD antibody detects MCD protein by western blot analysis. A. 30 ug 293T whole cell lysate/extract B. 30 ug A431 whole cell lysate/extract C. 30 ug HeLa whole cell lysate/extract D. 30 ug HepG2 whole cell lysate/extract 7.5 % SDS-PAGE MCD antibody dilution: 1:500

Anti-MLYCD monoclonal antibody - DCABH-12373 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal
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