| Gene Symbol | MLYCD |
|---|---|
| Entrez Gene | 23417 |
| Alt Symbol | MCD |
| Species | Human |
| Gene Type | protein-coding |
| Description | malonyl-CoA decarboxylase |
| Other Description | malonyl coenzyme A decarboxylase|malonyl-CoA decarboxylase, mitochondrial |
| Swissprots | Q9UNU5 Q9Y3F2 O95822 |
| Accessions | EAW95513 O95822 AF090834 AAD48994 AF097832 AAD16177 AF153679 AAD34631 AK094095 BC000286 AAH00286 BC052592 AAH52592 NM_012213 NP_036345 |
| Function | Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. {ECO:0000269|PubMed:10455107, ECO:0000269|PubMed:15003260, ECO:0000269|PubMed:18314420, ECO:0000269|PubMed:23482565}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10417274}. Mitochondrion matrix {ECO:0000269|PubMed:10417274}. Peroxisome {ECO:0000269|PubMed:10417274}. Peroxisome matrix {ECO:0000250}. Note=Enzymatically active in all three subcellular compartments. {ECO:0000250}. |
| Tissue Specificity | Expressed in fibroblasts and hepatoblastoma cells (at protein level). Expressed strongly in heart, liver, skeletal muscle, kidney and pancreas. Expressed in myotubes. Expressed weakly in brain, placenta, spleen, thymus, testis, ovary and small intestine. {ECO:0000269|PubMed:10455107, ECO:0000269|PubMed:18314420}. |
| Top Pathways | Peroxisome, AMPK signaling pathway, beta-Alanine metabolism, Propanoate metabolism |
MLYCD CRISPR/Cas9 KO Plasmid (h) - sc-411738 from Santa Cruz Biotechnology
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MLYCD HDR Plasmid (h) - sc-411738-HDR from Santa Cruz Biotechnology
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MLYCD Double Nickase Plasmid (h) - sc-411738-NIC from Santa Cruz Biotechnology
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MLYCD Double Nickase Plasmid (h2) - sc-411738-NIC-2 from Santa Cruz Biotechnology
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MLYCD CRISPR Activation Plasmid (h) - sc-411738-ACT from Santa Cruz Biotechnology
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MLYCD CRISPR Activation Plasmid (h2) - sc-411738-ACT-2 from Santa Cruz Biotechnology
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MLYCD Lentiviral Activation Particles (h) - sc-411738-LAC from Santa Cruz Biotechnology
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MLYCD Lentiviral Activation Particles (h2) - sc-411738-LAC-2 from Santa Cruz Biotechnology
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MLYCD siRNA (h) - sc-93181 from Santa Cruz Biotechnology
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MLYCD shRNA Plasmid (h) - sc-93181-SH from Santa Cruz Biotechnology
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MLYCD shRNA (h) Lentiviral Particles - sc-93181-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU038801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14414 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14414 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05720 from Sigma-Aldrich
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MLYCD siRNA (Human) - CRH8256 from Cohesion Biosciences
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shRNA set against Human MLYCD (NM_012213.2) - SHH342728 from Creative biogene
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shRNA set against Human MLYCD(NM_012213.2) - SHH192941 from Creative biogene
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Human MLYCD siRNA - orb268758 from Biorbyt
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MLYCD shRNA Plasmid (Human) - CHH8256 from Cohesion Biosciences
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MLYCD miRNA 3'UTR clone - MiUTR1H-06339 from Creative biogene
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