| Gene Symbol |
MLYCD
|
| Entrez Gene |
23417
|
| Alt Symbol |
MCD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
malonyl-CoA decarboxylase
|
| Other Description |
malonyl coenzyme A decarboxylase|malonyl-CoA decarboxylase, mitochondrial
|
| Swissprots |
Q9UNU5 Q9Y3F2 O95822
|
| Accessions |
EAW95513 O95822 AF090834 AAD48994 AF097832 AAD16177 AF153679 AAD34631 AK094095 BC000286 AAH00286 BC052592 AAH52592 NM_012213 NP_036345
|
| Function |
Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. {ECO:0000269|PubMed:10455107, ECO:0000269|PubMed:15003260, ECO:0000269|PubMed:18314420, ECO:0000269|PubMed:23482565}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10417274}. Mitochondrion matrix {ECO:0000269|PubMed:10417274}. Peroxisome {ECO:0000269|PubMed:10417274}. Peroxisome matrix {ECO:0000250}. Note=Enzymatically active in all three subcellular compartments. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in fibroblasts and hepatoblastoma cells (at protein level). Expressed strongly in heart, liver, skeletal muscle, kidney and pancreas. Expressed in myotubes. Expressed weakly in brain, placenta, spleen, thymus, testis, ovary and small intestine. {ECO:0000269|PubMed:10455107, ECO:0000269|PubMed:18314420}.
|
| Top Pathways |
Peroxisome, AMPK signaling pathway, beta-Alanine metabolism, Propanoate metabolism
|