SIGLEC8

Gene Symbol SIGLEC8
Entrez Gene 27181
Alt Symbol SAF2, SIGLEC-8, SIGLEC8L
Species Human
Gene Type protein-coding
Description sialic acid binding Ig-like lectin 8
Other Description CDw329|SAF-2|sialic acid-binding Ig-like lectin 8|sialoadhesin family member 2
Swissprots Q9NYZ4 Q7Z728
Accessions AAG00573 EAW72018 EAW72019 EAW72020 Q9NYZ4 AF195092 AAF27622 AF223403 AAF34702 AF310234 AAK55140 AK290149 BAF82838 AK290412 BAF83101 AK295589 BAG58481 BC053319 AAH53319 DA388103 XM_011526734 XP_011525036 XM_011526735 XP_011525037 NM_014442 NP_055257
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed specifically on eosinophils.

Siglec-8 (C-17) - sc-47418 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Siglec-8 (H-153) - sc-367440 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-SIGLEC8 antibody - ab38578 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SIGLEC8 antibody (ab38578) at 1/100 dilutionLane 1 : Mouse liver tissue lysateLane 2 : HL60 cell lysate

Anti-SIGLEC8 antibody - ab79285 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-SIGLEC8 antibody (ab79285) at 0.3 µg/ml + MOLT4 lysate (in RIPA buffer) at 35 µg

Anti-SIGLEC8 antibody - ab190647 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SIGLEC8 antibody (ab190647) at 1/500 dilution + K562 cell extract at 30 µg

Anti-SIGLEC8 antibody - ab57190 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57190 SIGLEC8 antibody at 1ug/ml.

Anti-SIGLEC8 antibody - ab154115 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SIGLEC8 antibody (ab154115) at 1/1000 dilution + THP1 whole cell lysate at 30 µg

Anti-SIGLEC8 antibody [7C9] - ab103398 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 7C9

Anti-SIGLEC8 antibody - C-terminal - ab198690 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human brain tissue labeling SIGLEC8 with ab198690 at a 1/40 dilution.

Anti-SIGLEC8 Antibody (aa134-145) - LS-C87375 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.3 ug/ml) staining of MOLT4 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence

Anti-SIGLEC8 Antibody (C-Terminus) - LS-C345727 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of SIGL8 Antibody with human HepG2 Whole Cell lysate.

Anti-SIGLEC8 Antibody (aa373-406) - LS-C97831 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-SIGLEC8 Antibody (aa94-122) - LS-C161093 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SIGLEC8 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Siglec-8 Antibody - NBP1-31141 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Siglec-8 Antibody [NBP1-31141] - A431 7.5% SDS PAGE diluted at 1:1000

Siglec-8 Antibody (837535) [Unconjugated] - MAB7975 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 837535
Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 PE-conjugated Monoclonal Antibody (Catalog # FAB155P) and either (A) Mouse Anti-Human Siglec-8 Monoclonal Antibody (Catalog # MAB7975) or (B) Mouse IgG1 Isotype Control (Catalog # MAB002) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B).

Siglec-8 Antibody - NBP1-06078 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Siglec-8 Antibody - NBP1-82666 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Siglec-8 Antibody [NBP1-82666] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes.

Siglec-8 Antibody - NBP2-20361 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SIGLEC8 Antibody [NBP2-20361] - Sample (30 ug of whole cell lysate) A: THP-1 10% SDS PAGE gel, diluted at 1:1000.

Siglec-8 Antibody (3H1) - H00027181-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3H1
ELISA: Siglec-8 Antibody (3H1) [H00027181-M03] - Detection limit for recombinant GST tagged SIGLEC8 is approximately 3ng/ml as a capture antibody.

Siglec-8 Antibody - H00027181-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Siglec-8 Antibody (837535) [Alexa Fluor 700] - FAB7975N from Novus Biologicals

Prices $339.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 837535
Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 PE-conjugated Monoclonal Antibody (Catalog # FAB155P) and either (A) Mouse Anti-Human Siglec-8 Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # FAB7975N) or (B) Mouse IgG1 Alexa Fluor 700 Isotype Control (Catalog # IC002N). View our protocol for Staining Membrane-associated Proteins.

Siglec-8 Antibody (837535) [Alexa Fluor 488] - FAB7975G from Novus Biologicals

Prices $339.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 837535
Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 APC-conjugated Monoclonal Antibody (Catalog # FAB155A) and either (A) Mouse Anti-Human Siglec-8 Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB7975G) or (B) Mouse IgG1 Alexa Fluor 488 Isotype Control (Catalog # IC002G). View our protocol for Staining Membrane-associated Proteins.

Siglec-8 Antibody (837535) [Allophycocyanin] - FAB7975A from Novus Biologicals

Prices $359.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 837535
Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 PE-conjugated Monoclonal Antibody (Catalog # FAB155P) and either (A) Mouse Anti-Human Siglec-8 APC-conjugated Monoclonal Antibody (Catalog # FAB7975A) or (B) Mouse IgG1 Allophycocyanin Isotype Control (Catalog # IC002A). View our protocol for Staining Membrane-associated Proteins.

Siglec-8 Antibody (837535) [Phycoerythrin] - FAB7975P from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 837535
Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 APC-conjugated Monoclonal Antibody (Catalog # FAB155A) and either (A) Mouse Anti-Human Siglec-8 PE-conjugated Monoclonal Antibody (Catalog # FAB7975P) or (B) Mouse IgG1 Phycoerythrin Isotype Control (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.

Siglec-8 Antibody (837535) [PerCP (Peridinin-chlorophyll Protein Complex)] - FAB7975C from Novus Biologicals

Prices $369.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 837535
Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB155F) and either (A) Mouse Anti-Human Siglec-8 PerCP-conjugated Monoclonal Antibody (Catalog # FAB7975C) or (B) Mouse IgG1 PerCP Isotype Control (Catalog # IC002C). View our protocol for Staining Membrane-associated Proteins.
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