Gene Symbol |
SIGLEC8
|
Entrez Gene |
27181
|
Alt Symbol |
SAF2, SIGLEC-8, SIGLEC8L
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
sialic acid binding Ig-like lectin 8
|
Other Description |
CDw329|SAF-2|sialic acid-binding Ig-like lectin 8|sialoadhesin family member 2
|
Swissprots |
Q9NYZ4 Q7Z728
|
Accessions |
AAG00573 EAW72018 EAW72019 EAW72020 Q9NYZ4 AF195092 AAF27622 AF223403 AAF34702 AF310234 AAK55140 AK290149 BAF82838 AK290412 BAF83101 AK295589 BAG58481 BC053319 AAH53319 DA388103 XM_011526734 XP_011525036 XM_011526735 XP_011525037 NM_014442 NP_055257
|
Function |
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
|
Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
Tissue Specificity |
Expressed specifically on eosinophils.
|