APITD1

Gene Symbol	APITD1
Entrez Gene	378708
Alt Symbol	CENP-S, CENPS, FAAP16, MHF1
Species	Human
Gene Type	protein-coding
Description	apoptosis-inducing, TAF9-like domain 1
Other Description	FANCM-interacting histone fold protein 1|Fanconi anemia-associated polypeptide of 16 kDa|apoptosis-inducing TAF9-like domain-containing protein 1|centromere protein S
Swissprots	Q8NFG5 Q8N2Z9 Q8NFE5
Accessions	CAI19199 EAW71654 Q8N2Z9 BC029430 AAH29430 BE858209 BG213105 BG546364 BM905996 BU902753 CA311915 HQ447791 ADQ32275 NM_199294 NP_954988 NR_036462
Function	DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segr
Subcellular Location	Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:15328517}.
Top Pathways	Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

APITD1-Over-expression-Lysate - LY15811a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

APITD1 293T Cell Transient Overexpression Lysate(Denatured) - H00378708-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

APITD1 overexpression lysate - LY404846 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

APITD1 overexpression lysate - LY430747 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

APITD1 overexpression lysate - LY433922 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

APITD1 Overexpression Lysate (Native) - NBL1-07604 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

APITD1 Overexpression Lysate (Native) - NBP2-04680 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

APITD1 Overexpression Lysate (Native) - NBP2-10083 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

APITD1 Overexpression Lysate (Denatured) - H00378708-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human APITD1 Knockdown Stable Cell Line - CSC-DC000757 from Creative biogene Category Cell Line Species Human

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