| Gene Symbol |
APITD1
|
| Entrez Gene |
378708
|
| Alt Symbol |
CENP-S, CENPS, FAAP16, MHF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apoptosis-inducing, TAF9-like domain 1
|
| Other Description |
FANCM-interacting histone fold protein 1|Fanconi anemia-associated polypeptide of 16 kDa|apoptosis-inducing TAF9-like domain-containing protein 1|centromere protein S
|
| Swissprots |
Q8NFG5 Q8N2Z9 Q8NFE5
|
| Accessions |
CAI19199 EAW71654 Q8N2Z9 BC029430 AAH29430 BE858209 BG213105 BG546364 BM905996 BU902753 CA311915 HQ447791 ADQ32275 NM_199294 NP_954988 NR_036462
|
| Function |
DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segr
|
| Subcellular Location |
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:15328517}.
|
| Top Pathways |
Fanconi anemia pathway
|