APITD1
| Gene Symbol | APITD1 |
|---|---|
| Entrez Gene | 378708 |
| Alt Symbol | CENP-S, CENPS, FAAP16, MHF1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | apoptosis-inducing, TAF9-like domain 1 |
| Other Description | FANCM-interacting histone fold protein 1|Fanconi anemia-associated polypeptide of 16 kDa|apoptosis-inducing TAF9-like domain-containing protein 1|centromere protein S |
| Swissprots | Q8NFG5 Q8N2Z9 Q8NFE5 |
| Accessions | CAI19199 EAW71654 Q8N2Z9 BC029430 AAH29430 BE858209 BG213105 BG546364 BM905996 BU902753 CA311915 HQ447791 ADQ32275 NM_199294 NP_954988 NR_036462 |
| Function | DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segr |
| Subcellular Location | Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:15328517}. |
| Top Pathways | Fanconi anemia pathway |
CENP-S CRISPR/Cas9 KO Plasmid (h) - sc-417249 from Santa Cruz Biotechnology
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CENP-S HDR Plasmid (h) - sc-417249-HDR from Santa Cruz Biotechnology
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CENP-S Double Nickase Plasmid (h) - sc-417249-NIC from Santa Cruz Biotechnology
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CENP-S Double Nickase Plasmid (h2) - sc-417249-NIC-2 from Santa Cruz Biotechnology
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CENP-S CRISPR Activation Plasmid (h) - sc-417249-ACT from Santa Cruz Biotechnology
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CENP-S CRISPR Activation Plasmid (h2) - sc-417249-ACT-2 from Santa Cruz Biotechnology
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CENP-S Lentiviral Activation Particles (h) - sc-417249-LAC from Santa Cruz Biotechnology
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CENP-S Lentiviral Activation Particles (h2) - sc-417249-LAC-2 from Santa Cruz Biotechnology
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CENP-S siRNA (h) - sc-105197 from Santa Cruz Biotechnology
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CENP-S shRNA Plasmid (h) - sc-105197-SH from Santa Cruz Biotechnology
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CENP-S shRNA (h) Lentiviral Particles - sc-105197-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU097121 from Sigma-Aldrich
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MISSION® esiRNA - EHU100481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3320 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3320 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04031 from Sigma-Aldrich
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APITD1 siRNA (Human) - CRJ7698 from Cohesion Biosciences
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APITD1 RNAi - H00378708-R03 from Novus Biologicals
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APITD1 RNAi - H00378708-R02 from Novus Biologicals
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APITD1 RNAi - H00378708-R01 from Novus Biologicals
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Human APITD1 siRNA - orb278199 from Biorbyt
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APITD1 shRNA Plasmid (Human) - CHJ7698 from Cohesion Biosciences
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APITD1 miRNA 3'UTR clone - MiUTR3H-10426 from Creative biogene
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