APITD1

Gene Symbol APITD1
Entrez Gene 378708
Alt Symbol CENP-S, CENPS, FAAP16, MHF1
Species Human
Gene Type protein-coding
Description apoptosis-inducing, TAF9-like domain 1
Other Description FANCM-interacting histone fold protein 1|Fanconi anemia-associated polypeptide of 16 kDa|apoptosis-inducing TAF9-like domain-containing protein 1|centromere protein S
Swissprots Q8NFG5 Q8N2Z9 Q8NFE5
Accessions CAI19199 EAW71654 Q8N2Z9 BC029430 AAH29430 BE858209 BG213105 BG546364 BM905996 BU902753 CA311915 HQ447791 ADQ32275 NM_199294 NP_954988 NR_036462
Function DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segr
Subcellular Location Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:15328517}.
Top Pathways Fanconi anemia pathway

MHF1 protein (His-DHFR tag) - ab127775 from Abcam

Category Protein
Source E. coli
Species Human

APITD1 Antibody Blocking Peptide - LS-E7646 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

APITD1 Recombinant Protein - H00378708-P01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

APITD1-Antibody-Center-Blocking-Peptide - BP4921c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CENP-S - H00378708-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

CENP-S - H00378708-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

APITD1 fusion protein - ag2529 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human Centromere protein S(APITD1) - CSB-YP839787HU CSB-EP839787HU CSB-BP839787HU CSB-MP839787HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

APITD1 Protein - abx163190 from Abbexa

Category Protein
Species Human

Centromere protein S (APITD1), Recombinant Protein - MBS1315216 from MyBioSource

Category Protein
Prices $875.00, $875.00, $1,100.00, $1,100.00, $1,280.00, $1,280.00, $1,735.00, $1,735.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

APITD1 Peptide, Human - M34GP00757H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human
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