| Gene Symbol |
TRPC6
|
| Entrez Gene |
7225
|
| Alt Symbol |
FSGS2, TRP6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily C, member 6
|
| Other Description |
TRP-6|focal segmental glomerulosclerosis 2|short transient receptor potential channel 6|transient receptor protein 6
|
| Swissprots |
Q9NQA8 Q9Y210 Q9HCW3 Q9NQA9 Q52M59
|
| Accessions |
EAW67003 EAW67004 EAW67005 Q9Y210 AF080394 AAC63289 AF086426 AJ006276 CAA06943 AJ007018 CAC06090 AJ271066 CAC01684 AJ271067 CAC01685 AJ271068 CAC01686 AK001960 AK027769 BAG51375 BC093658 AAH93658 BC093660 AAH93660 XM_006718898 XP_006718961 XM_011542968 XP_011541270 XM_011542969 XP_011541271 NM_004621 NP_004612
|
| Function |
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. {ECO:0000269|PubMed:15924139}.
|
| Top Pathways |
cGMP-PKG signaling pathway
|