TRPC6

Gene Symbol	TRPC6
Entrez Gene	7225
Alt Symbol	FSGS2, TRP6
Species	Human
Gene Type	protein-coding
Description	transient receptor potential cation channel, subfamily C, member 6
Other Description	TRP-6|focal segmental glomerulosclerosis 2|short transient receptor potential channel 6|transient receptor protein 6
Swissprots	Q9NQA8 Q9Y210 Q9HCW3 Q9NQA9 Q52M59
Accessions	EAW67003 EAW67004 EAW67005 Q9Y210 AF080394 AAC63289 AF086426 AJ006276 CAA06943 AJ007018 CAC06090 AJ271066 CAC01684 AJ271067 CAC01685 AJ271068 CAC01686 AK001960 AK027769 BAG51375 BC093658 AAH93658 BC093660 AAH93660 XM_006718898 XP_006718961 XM_011542968 XP_011541270 XM_011542969 XP_011541271 NM_004621 NP_004612
Function	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. {ECO:0000269|PubMed:15924139}.
Top Pathways	cGMP-PKG signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRPC6 peptide - ab51561 from Abcam Category Peptide Species Human

Human TRPC6 protein fragment - ab152771 from Abcam Category Protein Source Wheat germ Species Human

Mouse TRPC6 peptide - ab101502 from Abcam Category Peptide

TRPC6 peptide - ab106953 from Abcam Category Peptide

TRPC6 Antibody Blocking Peptide - LS-E30264 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRPC6 Antibody Blocking Peptide - LS-E30263 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRPC6 Antibody Blocking Peptide - LS-E25936 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRPC6 Antibody Blocking Peptide - LS-E26830 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRPC6 Antibody Blocking Peptide - LS-E27885 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TRPC6 Protein - H00007225-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRPC6 Blocking Peptide - NBP1-77261PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TRPC6 Blocking Peptide - NBP1-77260PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TRPC6 (C-term) blocking peptide - GTX88602-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Bovine

TRPC6 blocking peptide - GTX89496-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Bovine

Trpc6 Immunizing peptide - orb66391 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

TRPC6 Blocking Peptide - 33R-4464 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRPC6 Blocking Peptide - 33R-6482 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRPC6 Peptide - AC21-0765-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TRPC6 Peptide - AC21-1662-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TRPC6 / TRP6 - H00007225-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRPC6 / TRP6 - H00007225-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRPC6 / TRP6 Control Peptide - AP30956CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TRPC6 / TRP6 Control Peptide - AP30957CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TRPC6 Peptide - 3897P from ProSci Category Peptide Species Human

TRPC6 Peptide - 3899P from ProSci Category Peptide Species Human

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