TRPC6

Gene Symbol TRPC6
Entrez Gene 7225
Alt Symbol FSGS2, TRP6
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily C, member 6
Other Description TRP-6|focal segmental glomerulosclerosis 2|short transient receptor potential channel 6|transient receptor protein 6
Swissprots Q9NQA8 Q9Y210 Q9HCW3 Q9NQA9 Q52M59
Accessions EAW67003 EAW67004 EAW67005 Q9Y210 AF080394 AAC63289 AF086426 AJ006276 CAA06943 AJ007018 CAC06090 AJ271066 CAC01684 AJ271067 CAC01685 AJ271068 CAC01686 AK001960 AK027769 BAG51375 BC093658 AAH93658 BC093660 AAH93660 XM_006718898 XP_006718961 XM_011542968 XP_011541270 XM_011542969 XP_011541271 NM_004621 NP_004612
Function Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. {ECO:0000269|PubMed:15924139}.
Top Pathways cGMP-PKG signaling pathway

TRPC6 CRISPR/Cas9 KO Plasmid (h) - sc-401205 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPC6 HDR Plasmid (h) - sc-401205-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPC6 Double Nickase Plasmid (h) - sc-401205-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPC6 Double Nickase Plasmid (h2) - sc-401205-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPC6 CRISPR Activation Plasmid (h) - sc-401205-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPC6 CRISPR Activation Plasmid (h2) - sc-401205-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPC6 Lentiviral Activation Particles (h) - sc-401205-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPC6 Lentiviral Activation Particles (h2) - sc-401205-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPC6 siRNA (h) - sc-42672 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRPC6 shRNA Plasmid (h) - sc-42672-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRPC6 shRNA (h) Lentiviral Particles - sc-42672-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRPC6 RNAi - H00007225-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU116361 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2236 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2236 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09411 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09411

TRPC6 siRNA (Human) - CRH4949 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRPC6 - MBS8216176 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TRPC6 (NM_004621.5) - SHH435596 from Creative biogene

Category siRNA
Species Reactivities Human

Human TRPC6 siRNA - orb265451 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRPC6 shRNA Plasmid (Human) - CHH4949 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TRPC6 miRNA 3'UTR clone - MiUTR3H-06163 from Creative biogene

Species Reactivities Human
Search more