SF3B3

Gene Symbol SF3B3
Entrez Gene 23450
Alt Symbol RSE1, SAP130, SF3b130, STAF130
Species Human
Gene Type protein-coding
Description splicing factor 3b, subunit 3, 130kDa
Other Description SAP 130|pre-mRNA splicing factor SF3b, 130 kDa subunit|pre-mRNA-splicing factor SF3b 130 kDa subunit|spliceosome-associated protein 130|splicing factor 3B subunit 3|splicing factor 3b, subunit 3, 130kD
Swissprots Q9BPY2 Q96GC0 Q6NTI8 Q15393 Q9UJ29 Q9UFX7
Accessions EAW51803 EAW51804 EAW51805 Q15393 AJ001443 CAB56791 AK001297 BAG50889 AK074933 BAG52033 AK291768 BAF84457 AL110251 CAB53699 AW449427 BC000463 AAH00463 BC003146 AAH03146 BC009780 AAH09780 BC068974 AAH68974 BI465052 CB241776 D13642 BAA02805 D87686 BAA32662 JF432652 ADZ15869 NM_012426 NP_036558
Function Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Subcellular Location Nucleus {ECO:0000269|PubMed:11564863}.
Top Pathways Spliceosome

SF3B3 (B-4) - sc-398670 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SF3B3 (B-4): sc-398670. Western blot analysis of SF3B3 expression in Jurkat (A), U-937 (B), HeLa (C), RT-4 (D) and U-251-MG (E) whole cell lysates.

SF3B3 (D-2) - sc-514034 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SF3B3 (D-2): sc-514034. Western blot analysis of SF3B3 expression in Jurkat (A), U-937 (B), HeLa (C) and RT-4 (D) whole cell lysates and HeLa nuclear extract (E).

SF3B3 (H-300) - sc-366647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SF3B3 (H-300): sc-366647. Western blot analysis of SF3B3 expression in Jurkat (A), RAW 264.7 (B), IMR-32 (C) and U-937 (D) whole cell lysates.

SF3B3 (S-15) - sc-21324 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SF3B3 antibody - ab96683 from Abcam

Prices $385.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-SF3B3 antibody (ab96683) at 1/3000 dilution + HeLa whole cell lysate at 30 µg

Anti-SF3B3 antibody - ab124658 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab124658, at 1/500 dilution, staining SF3B3 in Formalin-fixed Paraffin-embedded Human ovarian carcinoma tissue, by Immunohistochemistry. Detection by DAB staining.

Anti-SF3B3 antibody - ab86992 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SF3B3 antibody (ab86992) at 1 µg/ml (in 5% skim milk / PBS buffer) + Transfected 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SF3B3 antibody - ab138010 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SF3B3 antibody (ab138010) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-SF3B130 / SF3B3 Antibody (aa1046-1074, AP) - LS-C269091 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B130 / SF3B3 Antibody (C-Terminus) - LS-C101867 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
SF3B3 antibody LS-C101867 Western blot of Transfected 293T cell lysate.

Anti-SF3B130 / SF3B3 Antibody (aa223-272) - LS-C200658 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HeLa cells using SF3B3 antibody.

Anti-SF3B130 / SF3B3 Antibody (aa1046-1074, APC) - LS-C269092 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B130 / SF3B3 Antibody (aa1046-1074, Biotin) - LS-C269093 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B130 / SF3B3 Antibody (aa1046-1074, FITC) - LS-C269094 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B130 / SF3B3 Antibody (aa1046-1074, Azide-free, HRP) - LS-C269095 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B130 / SF3B3 Antibody (aa1046-1074) - LS-C169008 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SF3B3 Antibody western blot of MDA-MB453,Jurkat cell line lysates (35 ug/lane). The SF3B3 antibody detected the SF3B3 protein (arrow).

Anti-SF3B130 / SF3B3 Antibody (aa1046-1074, PE) - LS-C269096 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B130 / SF3B3 Antibody (aa282-327) - LS-C313947 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SF3B130 / SF3B3 Antibody (aa1053-1082) - LS-C325032 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SF3B130 / SF3B3 Antibody (aa231-280) - LS-C291401 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SF3B130 / SF3B3 Antibody - LS-C332050 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SF3B130 / SF3B3 Antibody (aa1043-1092) - LS-C116181 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SF3B3 antibody LS-C116181 Western blot of HCT15 cell lysate.

Anti-SF3B130 / SF3B3 Antibody (C-Terminus) - LS-C345725 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of SF3B3 Antibody with human Fetal Liver lysate.

Anti-SF3B130 / SF3B3 Antibody (aa386-399) - LS-C55433 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining (0.1 ug/ml) of nuclear lysate from HeLa cells (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

Anti-SF3B130 / SF3B3 Antibody (aa1167-1217) - LS-C289242 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse SF3B3 by Immunohistochemistry. Sample: FFPE sections of human prostate carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-SF3B3 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
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