| Gene Symbol |
SF3B3
|
| Entrez Gene |
23450
|
| Alt Symbol |
RSE1, SAP130, SF3b130, STAF130
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
splicing factor 3b, subunit 3, 130kDa
|
| Other Description |
SAP 130|pre-mRNA splicing factor SF3b, 130 kDa subunit|pre-mRNA-splicing factor SF3b 130 kDa subunit|spliceosome-associated protein 130|splicing factor 3B subunit 3|splicing factor 3b, subunit 3, 130kD
|
| Swissprots |
Q9BPY2 Q96GC0 Q6NTI8 Q15393 Q9UJ29 Q9UFX7
|
| Accessions |
EAW51803 EAW51804 EAW51805 Q15393 AJ001443 CAB56791 AK001297 BAG50889 AK074933 BAG52033 AK291768 BAF84457 AL110251 CAB53699 AW449427 BC000463 AAH00463 BC003146 AAH03146 BC009780 AAH09780 BC068974 AAH68974 BI465052 CB241776 D13642 BAA02805 D87686 BAA32662 JF432652 ADZ15869 NM_012426 NP_036558
|
| Function |
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11564863}.
|
| Top Pathways |
Spliceosome
|
