SERPINB6

Gene Symbol SERPINB6
Entrez Gene 5269
Alt Symbol CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3
Species Human
Gene Type protein-coding
Description serpin peptidase inhibitor, clade B (ovalbumin), member 6
Other Description cytoplasmic antiproteinase|protease inhibitor 6 (placental thrombin inhibitor)|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6|serpin B6
Swissprots Q96J44 Q7Z2Y7 B2RBA8 Q5TD06 Q9UDI7 P35237 Q59F97
Accessions EAW55097 EAW55098 EAW55099 EAW55100 EAW55101 EAW55102 EAW55103 EAW55104 EAW55105 EAW55106 P35237 AB209563 BAD92800 AF116727 AAO15303 AK027149 AK056729 AK057138 AK094983 AK098566 AK122895 AK122961 AK128637 AK314578 BAG37155 BC001394 AAH01394 BC098564 AAH98564 BG499326 BI090002 BI259189 BI827451 BM789272 BP325314 BP370484 BQ681973 BX375950 BX538343 CAD98106 CA847860 CD674931 CX755337 CX782163 DA847833 DQ895367 ABM86293 EU176348 ABW03799 HY169891 Z22658 CAA80373 XM_011514672 XP_011512974 XM_011514673 XP_011512975 XM_011514674 XP_011512976 XM_011514675 XP_011512977 XM_011514676 XP_011512978 NM_001195291 NP_001182220 NM_001271822 NP_001258751 NM_001271823 NP_001258752 NM_001271824 NP_001258753 NM_001271825 NP_001258754 NM_001297699 NP_001284628 NM_001297700 NP_001284629 NM_004568 NP_004559
Function May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. {ECO:0000250, ECO:0000269|PubMed:10068683, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8136380, ECO:0000269|PubMed:8415716}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8486644}.
Tissue Specificity Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170}.
Top Pathways Amoebiasis

SerpinB6 (E-8) - sc-398487 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SerpinB6 (E-8): sc-398487. Western blot analysis of SerpinB6 expression in A549 (A) and MCF7 (B) whole cell lysates.

SerpinB6 (G-5) - sc-398463 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SerpinB6 (G-5): sc-398463. Western blot analysis of SerpinB6 expression in Caki-1 (A), MCF7 (B) and HeLa (C) whole cell lysates.

SerpinB6 (F-12) - sc-21143 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of SerpinB6 expression in NIH/ 3T3 whole cell lysate (A,B). Antibodies tested include SerpinB6 (F-12): sc-21143 (A) and SerpinB6 (M-12): sc-21145 (B).

SerpinB6 (H-48) - sc-292536 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SerpinB6 (H-48): sc-292536. Western blot analysis of SerpinB6 expression in NIH/3T3 whole cell lysate.

SerpinB6 (Y-16) - sc-21135 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PI-6 (Y-16): sc-21135. Immunofluorescence staining of methanol-fixed A549 cells showing cytoplasmic localization.

Anti-SerpinB6 antibody - ab109695 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SerpinB6 antibody (ab109695) at 1/500 dilutionLane 1 : Human fetal lung lysateLane 2 : Human fetal liver lysateLane 3 : Human fetal kidney lysate

Anti-SerpinB6 antibody - ab77372 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-SerpinB6 antibody (ab77372) at 0.1 µg/ml + human ovary lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-SerpinB6 antibody - ab97330 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SerpinB6 antibody (ab97330) at 1/1000 dilutionLane 1 : A549 whole cell lysateLane 2 : HeLa whole cell lysateLysates/proteins at 30 µg per lane.

Anti-SerpinB6 antibody - ab47735 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SerpinB6 antibody [1C5] - ab119792 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C5
All lanes : Anti-SerpinB6 antibody [1C5] (ab119792) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNA Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SerpinB6 cDNA Lysates/proteins at 5 µg per lane.

Anti-SerpinB6 antibody [2F8] - ab119393 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F8
All lanes : Anti-SerpinB6 antibody [2F8] (ab119393) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SerpinB6 Lysates/proteins at 5 µg per lane.

Anti-SERPINB6 / PI-6 Antibody (clone 1C5) - LS-C337593 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C5
IHC of paraffin-embedded Human liver tissue using anti-SERPINB6 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-SERPINB6 / PI-6 Antibody (aa161-210) - LS-C116932 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SERPINB6 antibody LS-C116932 Western blot of Placenta lysate.

Anti-SERPINB6 / PI-6 Antibody (aa172-185) - LS-C55454 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.1 ug/ml) staining of Human Ovary lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SERPINB6 / PI-6 Antibody (aa66-313) - LS-C186373 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded breast ca using SERPINB6 antibody antibody at 1:500 dilution.

Anti-SERPINB6 / PI-6 Antibody (clone 2F8) - LS-C337580 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2F8
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-SERPINB6 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-SERPINB6 / PI-6 Antibody (clone 3H3) - LS-C173776 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H3
Anti-SERPINB6 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SERPINB6.

Anti-SERPINB6 / PI-6 Antibody (aa2-376, Biotin) - LS-C75741 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

Anti-SERPINB6 / PI-6 Antibody (clone 3A) - LS-C140593 from LifeSpan Bioscience

Prices $460.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A

Anti-SERPINB6 / PI-6 Antibody (clone 3A) - LS-C146988 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A

Anti-SERPINB6 / PI-6 Antibody - LS-C178438 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Serpin B6 Antibody (1C5) - NBP2-01650 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C5

Serpin B6 Antibody - NBP1-86642 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SerpinB6 Antibody [NBP1-86642] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

Serpin B6 Antibody [Unconjugated] - AF4336 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Serpin B6 Antibody - NBP1-86643 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SerpinB6 Antibody [NBP1-86643] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp
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