SERPINB6

Gene Symbol	SERPINB6
Entrez Gene	5269
Alt Symbol	CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3
Species	Human
Gene Type	protein-coding
Description	serpin peptidase inhibitor, clade B (ovalbumin), member 6
Other Description	cytoplasmic antiproteinase|protease inhibitor 6 (placental thrombin inhibitor)|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6|serpin B6
Swissprots	Q96J44 Q7Z2Y7 B2RBA8 Q5TD06 Q9UDI7 P35237 Q59F97
Accessions	EAW55097 EAW55098 EAW55099 EAW55100 EAW55101 EAW55102 EAW55103 EAW55104 EAW55105 EAW55106 P35237 AB209563 BAD92800 AF116727 AAO15303 AK027149 AK056729 AK057138 AK094983 AK098566 AK122895 AK122961 AK128637 AK314578 BAG37155 BC001394 AAH01394 BC098564 AAH98564 BG499326 BI090002 BI259189 BI827451 BM789272 BP325314 BP370484 BQ681973 BX375950 BX538343 CAD98106 CA847860 CD674931 CX755337 CX782163 DA847833 DQ895367 ABM86293 EU176348 ABW03799 HY169891 Z22658 CAA80373 XM_011514672 XP_011512974 XM_011514673 XP_011512975 XM_011514674 XP_011512976 XM_011514675 XP_011512977 XM_011514676 XP_011512978 NM_001195291 NP_001182220 NM_001271822 NP_001258751 NM_001271823 NP_001258752 NM_001271824 NP_001258753 NM_001271825 NP_001258754 NM_001297699 NP_001284628 NM_001297700 NP_001284629 NM_004568 NP_004559
Function	May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. {ECO:0000250, ECO:0000269|PubMed:10068683, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8136380, ECO:0000269|PubMed:8415716}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8486644}.
Tissue Specificity	Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170}.
Top Pathways	Amoebiasis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SerpinB6 full length protein - ab132516 from Abcam Category Protein Source Wheat germ Species Human

Human SerpinB6 full length protein - ab152010 from Abcam Category Protein Source E. coli Species Human

Human SerpinB6 protein fragment - ab127101 from Abcam Category Protein Source E. coli Species Human

SERPINB6 / PI-6 Antibody Blocking Peptide - LS-E21668 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SERPINB6 / PI-6 Antibody Blocking Peptide - LS-E26736 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Serpin B6 Protein - H00005269-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SERPINB6 blocking peptide - GTX88711-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human SerpinB6 His tag protein - orb84572 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source Insect Species Human

Human SERPIN B6 protein - orb49163 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

SERPINB6 Blocking Peptide - 33R-5526 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SERPINB6 Peptide - AC21-1573-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SERPINB6 / PI6 - H00005269-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SERPINB6 / PI6 - H00005269-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Serpin B6, Human, Recombinant - 19-CE54 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

SERPINB6 Peptide - 46-358P from ProSci Category Peptide Species Human

SERPINB6 fusion protein - Ag7140 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SERPINB6 fusion protein - Ag6824 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Serpin B6 Enzyme - BP001689-CE54 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human SERPINB6, His tagged - SERPINB6-7025H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human SERPINB6, His-tagged - SERPINB6-7781H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human SERPINB6, His-tagged - SERPINB6-2595H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Placental Thrombin Inhibitor (PTI) - RPD388Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Placental Thrombin Inhibitor (PTI) - RPD388Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Serpin B6(SERPINB6) - CSB-YP021074HU CSB-EP021074HU CSB-BP021074HU CSB-MP021074HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SERPINB6 / PI6 - TP300668 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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