SERPINB6

Gene Symbol SERPINB6
Entrez Gene 5269
Alt Symbol CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3
Species Human
Gene Type protein-coding
Description serpin peptidase inhibitor, clade B (ovalbumin), member 6
Other Description cytoplasmic antiproteinase|protease inhibitor 6 (placental thrombin inhibitor)|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6|serpin B6
Swissprots Q96J44 Q7Z2Y7 B2RBA8 Q5TD06 Q9UDI7 P35237 Q59F97
Accessions EAW55097 EAW55098 EAW55099 EAW55100 EAW55101 EAW55102 EAW55103 EAW55104 EAW55105 EAW55106 P35237 AB209563 BAD92800 AF116727 AAO15303 AK027149 AK056729 AK057138 AK094983 AK098566 AK122895 AK122961 AK128637 AK314578 BAG37155 BC001394 AAH01394 BC098564 AAH98564 BG499326 BI090002 BI259189 BI827451 BM789272 BP325314 BP370484 BQ681973 BX375950 BX538343 CAD98106 CA847860 CD674931 CX755337 CX782163 DA847833 DQ895367 ABM86293 EU176348 ABW03799 HY169891 Z22658 CAA80373 XM_011514672 XP_011512974 XM_011514673 XP_011512975 XM_011514674 XP_011512976 XM_011514675 XP_011512977 XM_011514676 XP_011512978 NM_001195291 NP_001182220 NM_001271822 NP_001258751 NM_001271823 NP_001258752 NM_001271824 NP_001258753 NM_001271825 NP_001258754 NM_001297699 NP_001284628 NM_001297700 NP_001284629 NM_004568 NP_004559
Function May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. {ECO:0000250, ECO:0000269|PubMed:10068683, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8136380, ECO:0000269|PubMed:8415716}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8486644}.
Tissue Specificity Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170}.
Top Pathways Amoebiasis

SERPINB6-Over-expression-Lysate - LY14064a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag SERPINB6 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SERPINB6 gene.

SERPINB6 293T Cell Transient Overexpression Lysate(Denatured) - H00005269-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

Serpin B6 Overexpression Lysate (Native) - NBP2-07855 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: SerpinB6 Overexpression Lysate (Adult Normal) [NBP2-07855] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SerpinB6.

SerpinB6 (h): 293T - sc-173828 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Human SerpinB6 / PI-6 Insect Cell Lysate (WB positive control) - 12837-H07BL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Serpin B6 Overexpression Lysate (Denatured) - H00005269-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Human SerpinB6 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175069 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Panoply™ Human SERPINB6 Knockdown Stable Cell Line - CSC-DC014052 from Creative biogene

Category Cell Line
Species Human
Search more