SERPINB6

Gene Symbol	SERPINB6
Entrez Gene	5269
Alt Symbol	CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3
Species	Human
Gene Type	protein-coding
Description	serpin peptidase inhibitor, clade B (ovalbumin), member 6
Other Description	cytoplasmic antiproteinase|protease inhibitor 6 (placental thrombin inhibitor)|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6|serpin B6
Swissprots	Q96J44 Q7Z2Y7 B2RBA8 Q5TD06 Q9UDI7 P35237 Q59F97
Accessions	EAW55097 EAW55098 EAW55099 EAW55100 EAW55101 EAW55102 EAW55103 EAW55104 EAW55105 EAW55106 P35237 AB209563 BAD92800 AF116727 AAO15303 AK027149 AK056729 AK057138 AK094983 AK098566 AK122895 AK122961 AK128637 AK314578 BAG37155 BC001394 AAH01394 BC098564 AAH98564 BG499326 BI090002 BI259189 BI827451 BM789272 BP325314 BP370484 BQ681973 BX375950 BX538343 CAD98106 CA847860 CD674931 CX755337 CX782163 DA847833 DQ895367 ABM86293 EU176348 ABW03799 HY169891 Z22658 CAA80373 XM_011514672 XP_011512974 XM_011514673 XP_011512975 XM_011514674 XP_011512976 XM_011514675 XP_011512977 XM_011514676 XP_011512978 NM_001195291 NP_001182220 NM_001271822 NP_001258751 NM_001271823 NP_001258752 NM_001271824 NP_001258753 NM_001271825 NP_001258754 NM_001297699 NP_001284628 NM_001297700 NP_001284629 NM_004568 NP_004559
Function	May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. {ECO:0000250, ECO:0000269|PubMed:10068683, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8136380, ECO:0000269|PubMed:8415716}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8486644}.
Tissue Specificity	Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170}.
Top Pathways	Amoebiasis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SERPINB6 / PI-6 ELISA Kit (Sandwich ELISA) - LS-F9784 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Human SERPINB6 / PI-6 ELISA Kit (Sandwich ELISA) - LS-F12649 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Bovine SERPINB6 / PI-6 ELISA Kit (Sandwich ELISA) - LS-F12650 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Serpin B6, SERPINB6, Human, ELISA Kit - E11772h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

serpin peptidase inhibitor, clade B (ovalbumin) , member 6, ELISA Kit - MBS943550 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human SERPINB6 is typically less than 0.039 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.156 ng/ml -10 ng/ml.

ELISA Kit for Placental Thrombin Inhibitor (PTI) - SED388Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Serpin B6(SERPINB6) ELISA kit - CSB-EL021074HU from Cusabio Category ELISA Kit Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

ELISA Kit for Placental Thrombin Inhibitor (PTI) - SED388Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse SERPINB6 / PI-6 ELISA Kit (Custom ELISA) - LS-F16310 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human PTI ELISA Kit - abx152890 from Abbexa Category ELISA Kit Sensitivity 0.059 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human Serpin B6 ELISA Kit - abx250616 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Custom Human Serpin B6 ELISA - ELH-SERPINB6 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Serpin B6 ELISA - RAB1690 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Human Serpin B6 (SERPINB6) ELISA Kit - EKC35533 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Human Serpin B6 ELISA Kit - EKE53188 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.15 ng/ml Range 0.312-20 ng/mL

SERPINB6 - EKH2694 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

SERPINB6 ELISA Kit (Human) (OKEH02186) - OKEH02186 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.15 ng/mL Range 0.312 - 20 ng/mL

Custom Human Serpin B6 ELISA - ELH-SERPINB6-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human PTI ELISA Kit - E029541 from Biobool Category ELISA Kit Sensitivity Typically less than 0.059ng/mL.

Human SERPINB6 ELISA Kit - E034899 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human SERPINB6 is typically less than 0.039 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined th

Human Serpin B6 ELISA Kit - EK2893 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.15ng/ml Range 0.312-20 ng/mL

anti-SERPINB6 antibody - ARG64583 from Arigo Biolaboratories Category ELISA Kit

Serpin B6, ELISA Kit - MBS9426729 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.15ng/mL Range 0.312-20 ng/mL

Serpin B6, ELISA Kit - MBS2884607 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL

Human SERPINB6 / PI-6 ELISA Kit (Sandwich ELISA) - LS-F33282 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.188 Range 0.156-10 ng/ml

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