| Gene Symbol |
SERPINB6
|
| Entrez Gene |
5269
|
| Alt Symbol |
CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serpin peptidase inhibitor, clade B (ovalbumin), member 6
|
| Other Description |
cytoplasmic antiproteinase|protease inhibitor 6 (placental thrombin inhibitor)|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6|serpin B6
|
| Swissprots |
Q96J44 Q7Z2Y7 B2RBA8 Q5TD06 Q9UDI7 P35237 Q59F97
|
| Accessions |
EAW55097 EAW55098 EAW55099 EAW55100 EAW55101 EAW55102 EAW55103 EAW55104 EAW55105 EAW55106 P35237 AB209563 BAD92800 AF116727 AAO15303 AK027149 AK056729 AK057138 AK094983 AK098566 AK122895 AK122961 AK128637 AK314578 BAG37155 BC001394 AAH01394 BC098564 AAH98564 BG499326 BI090002 BI259189 BI827451 BM789272 BP325314 BP370484 BQ681973 BX375950 BX538343 CAD98106 CA847860 CD674931 CX755337 CX782163 DA847833 DQ895367 ABM86293 EU176348 ABW03799 HY169891 Z22658 CAA80373 XM_011514672 XP_011512974 XM_011514673 XP_011512975 XM_011514674 XP_011512976 XM_011514675 XP_011512977 XM_011514676 XP_011512978 NM_001195291 NP_001182220 NM_001271822 NP_001258751 NM_001271823 NP_001258752 NM_001271824 NP_001258753 NM_001271825 NP_001258754 NM_001297699 NP_001284628 NM_001297700 NP_001284629 NM_004568 NP_004559
|
| Function |
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. {ECO:0000250, ECO:0000269|PubMed:10068683, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8136380, ECO:0000269|PubMed:8415716}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8486644}.
|
| Tissue Specificity |
Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170}.
|
| Top Pathways |
Amoebiasis
|