F2

Gene Symbol F2
Entrez Gene 2147
Alt Symbol PT, RPRGL2, THPH1
Species Human
Gene Type protein-coding
Description coagulation factor II (thrombin)
Other Description prepro-coagulation factor II|prothrombin|prothrombin B-chain|serine protease
Swissprots Q53H06 B2R7F7 P00734 Q7Z7P3 Q4QZ40 Q53H04 Q9UCA1 B4E1A7 Q69EZ7
Accessions AAB24476 AAC63054 AAL77436 AAM11680 CAD80258 CAL24231 EAW67977 EAW67978 EAW67979 P00734 AJ972449 CAJ01369 AK222775 BAD96495 AK222777 BAD96497 AK293326 BAG56844 AK303747 BAG64719 AK312965 BAG35804 AY344793 AAR08142 AY344794 AAR08143 BC051332 AAH51332 CB156997 DB183734 EU832664 ACE87755 EU832742 ACE87074 M33031 AAA60220 V00595 CAA23842 XR_428840 NM_000506 NP_000497
Function Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. {ECO:0000269|PubMed:2856554}.
Subcellular Location Secreted, extracellular space.
Tissue Specificity Expressed by the liver and secreted in plasma.
Top Pathways Complement and coagulation cascades, Regulation of actin cytoskeleton, Neuroactive ligand-receptor interaction

cleaved Prothrombin (h44) - sc-23327 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Prothrombin (12) - sc-136449 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Prothrombin (12): sc-136449. Western blot analysis of Prothrombin in human plasma tissue extract.

Prothrombin (28H5) - sc-69769 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Prothrombin (28H5): sc-69769. Western blot analysis of Prothrombin purified from human plasma (A) and in human plasma (B).

Prothrombin (AHP-5013) - sc-73470 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Prothrombin (AHP-5013): sc-73470. Western blot analysis of Prothrombin expression in human platelet extract.

Thrombin (F-1) - sc-271449 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Thrombin (F-1): sc-271449. Western blot analysis of Prothrombin expression in non-transfected 293T: sc-117752 (A), human Prothrombin transfected 293T: sc-177784 (B) and NIH/3T3 (C) whole cell lysates.

Thrombin (K-20) - sc-16972 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Thrombin (K-20): sc-16972. Western blot analysis of Prothrombin expression in human platelet extract.

Thrombin (GMA-020) - sc-65961 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Thrombin API (D-9) - sc-376933 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Thrombin API (D-9): sc-376933. Western blot analysis of Prothrombin expression in non-transfected: sc-117752 (A) and mouse Prothrombin transfected: sc-127389 (B) 293T whole cell lysates.

Thrombin API (A-16) - sc-23337 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Thrombin API (A-16): sc-23337. Western blot analysis of Thrombin API protein purified from human plasma.

Thrombin API (H-85) - sc-33769 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Thrombin API (H-85): sc-33769. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nuclear localization.

Thrombin HC (L-15) - sc-23352 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Thrombin HC (L-15): sc-23352. Western blot analysis of Thrombin HC expression in SH-SY5Y whole cell lysate.

Thrombin LC (T-17) - sc-23348 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

cleaved Thrombin API (h198) - sc-23328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cleaved Thrombin API (h198): sc-23328. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

Anti-Gamma Thrombin antibody - ab136993 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Gamma Thrombin antibody - ab189422 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Gamma Thrombin antibody (ab189422) at 1/500 dilutionLane 1 : Jurkat cell extracts, treated with etoposide 25 uM for 24 hoursLane 2 : Jurkat cell extracts, treated with etoposide 25 uM for 24 hours with synthesized peptide.

Anti-Prothrombin antibody - ab48627 from Abcam

Prices $379.00
Sizes 150 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab48627 stained HepG2 cells. The cells were 4% PFA fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab48627, 1µg/ml) overnight at +4°C. The secondary antibody (green)ÿwas Alexa Fluor© 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor© 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Prothrombin antibody - ab189074 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human liver tissue labeling Prothrombin with ab189074 at 5 µg/ml.

Anti-Prothrombin antibody - ab33926 from Abcam

Prices $370.00
Sizes 100 µg
Clonality Polyclonal

Anti-Prothrombin antibody - ab184015 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Prothrombin antibody (ab184015) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Prothrombin antibody - ab166598 from Abcam

Prices $368.00
Sizes 150 µg
Host Chicken
Clonality Polyclonal

Anti-Prothrombin antibody - ab166674 from Abcam

Prices $368.00
Sizes 150 µg
Host Chicken
Clonality Polyclonal

Anti-Prothrombin antibody [BDI095] - ab22700 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone BDI095

Anti-Prothrombin antibody (Biotin) - ab49554 from Abcam

Prices $370.00
Sizes 150 µg
Host Rabbit
Clonality Polyclonal

Anti-Prothrombin antibody (Biotin) - ab166599 from Abcam

Prices $368.00
Sizes 150 µg
Host Chicken
Clonality Polyclonal

Anti-Prothrombin antibody [EPR5188] - ab109087 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5188
All lanes : Anti-Prothrombin antibody [EPR5188] (ab109087) at 1/1000 dilutionLane 1 : Human serum lysateLane 2 : Human plasma lysateLane 3 : Human platelet lysateLysates/proteins at 10 µg per lane.
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