F2

Gene Symbol F2
Entrez Gene 2147
Alt Symbol PT, RPRGL2, THPH1
Species Human
Gene Type protein-coding
Description coagulation factor II (thrombin)
Other Description prepro-coagulation factor II|prothrombin|prothrombin B-chain|serine protease
Swissprots Q53H06 B2R7F7 P00734 Q7Z7P3 Q4QZ40 Q53H04 Q9UCA1 B4E1A7 Q69EZ7
Accessions AAB24476 AAC63054 AAL77436 AAM11680 CAD80258 CAL24231 EAW67977 EAW67978 EAW67979 P00734 AJ972449 CAJ01369 AK222775 BAD96495 AK222777 BAD96497 AK293326 BAG56844 AK303747 BAG64719 AK312965 BAG35804 AY344793 AAR08142 AY344794 AAR08143 BC051332 AAH51332 CB156997 DB183734 EU832664 ACE87755 EU832742 ACE87074 M33031 AAA60220 V00595 CAA23842 XR_428840 NM_000506 NP_000497
Function Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. {ECO:0000269|PubMed:2856554}.
Subcellular Location Secreted, extracellular space.
Tissue Specificity Expressed by the liver and secreted in plasma.
Top Pathways Complement and coagulation cascades, Regulation of actin cytoskeleton, Neuroactive ligand-receptor interaction

Prothrombin CRISPR/Cas9 KO Plasmid (h) - sc-400962 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Prothrombin HDR Plasmid (h) - sc-400962-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Prothrombin Double Nickase Plasmid (h) - sc-400962-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Prothrombin Double Nickase Plasmid (h2) - sc-400962-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Prothrombin CRISPR Activation Plasmid (h) - sc-400962-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Prothrombin CRISPR Activation Plasmid (h2) - sc-400962-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Prothrombin Lentiviral Activation Particles (h) - sc-400962-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Prothrombin Lentiviral Activation Particles (h2) - sc-400962-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Prothrombin siRNA (h) - sc-40413 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Prothrombin shRNA Plasmid (h) - sc-40413-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Prothrombin shRNA (h) Lentiviral Particles - sc-40413-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU038181 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1096 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1096 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

F2 siRNA (Human) - CRH1492 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

F2 - MBS8203985 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Prothrombin CRISPR/Cas9 KO Plasmid (h2) - sc-400962-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Prothrombin HDR Plasmid (h2) - sc-400962-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

F2 shRNA Plasmid (Human) - CHH1492 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

F2 miRNA 3'UTR clone - MiUTR3H-01916 from Creative biogene

Species Reactivities Human
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