F2

Gene Symbol	F2
Entrez Gene	2147
Alt Symbol	PT, RPRGL2, THPH1
Species	Human
Gene Type	protein-coding
Description	coagulation factor II (thrombin)
Other Description	prepro-coagulation factor II|prothrombin|prothrombin B-chain|serine protease
Swissprots	Q53H06 B2R7F7 P00734 Q7Z7P3 Q4QZ40 Q53H04 Q9UCA1 B4E1A7 Q69EZ7
Accessions	AAB24476 AAC63054 AAL77436 AAM11680 CAD80258 CAL24231 EAW67977 EAW67978 EAW67979 P00734 AJ972449 CAJ01369 AK222775 BAD96495 AK222777 BAD96497 AK293326 BAG56844 AK303747 BAG64719 AK312965 BAG35804 AY344793 AAR08142 AY344794 AAR08143 BC051332 AAH51332 CB156997 DB183734 EU832664 ACE87755 EU832742 ACE87074 M33031 AAA60220 V00595 CAA23842 XR_428840 NM_000506 NP_000497
Function	Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. {ECO:0000269|PubMed:2856554}.
Subcellular Location	Secreted, extracellular space.
Tissue Specificity	Expressed by the liver and secreted in plasma.
Top Pathways	Complement and coagulation cascades, Regulation of actin cytoskeleton, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Beta Thrombin full length protein - ab81591 from Abcam Category Protein Prices $450.00 Sizes 100 µg Source Native Species Human

Active human Prethrombin 2 full length protein - ab62535 from Abcam Category Protein Prices $290.00 Sizes 250 µg Source Native Species Human

Cow Prothrombin full length protein - ab62537 from Abcam Category Protein Prices $181.00 Sizes 2 mg Source Native Species Bovine

Cow Prothrombin full length protein - ab167792 from Abcam Category Protein Prices $285.00 Sizes 1 mg Species Bovine

Human Alpha Thrombin full length protein - ab168719 from Abcam Category Protein Prices $285.00 Sizes 250 µg Source Native Species Human

Human Alpha Thrombin full length protein - ab81589 from Abcam Category Protein Prices $450.00 Sizes 100 µg Source Native Species Human

Human Alpha Thrombin full length protein - ab81590 from Abcam Category Protein Prices $450.00 Sizes 100 µg Source Native Species Human

Human Alpha Thrombin full length protein - ab81585 from Abcam Category Protein Prices $450.00 Sizes 100 µg Source Native Species Human

Human Prothrombin full length protein - ab158398 from Abcam Category Protein Source Wheat germ Species Human

Human Prothrombin full length protein - ab168909 from Abcam Category Protein Source Native Species Human

Human Prothrombin full length protein - ab62536 from Abcam Category Protein Source Native Species Human

Human Prothrombin full length protein - ab62506 from Abcam Category Protein Source Native Species Human

Human Prothrombin full length protein - ab180268 from Abcam Category Protein Source E. coli Species Human

Human Prothrombin protein fragment - ab158399 from Abcam Category Protein Source Wheat germ Species Human

Human Prothrombin protein fragment - ab62503 from Abcam Category Protein Source Native Species Human

Human Prothrombin protein fragment - ab62502 from Abcam Category Protein Source Native Species Human

Human Prothrombin protein fragment - ab62504 from Abcam Category Protein Source Native Species Human

Mouse Prothrombin full length protein - ab168892 from Abcam Category Protein Source Native Species Mouse

Recombinant Human Coagulation Factor II/Thrombin, CF - 1473-SE-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Met1-Glu622 with a C-terminal 10-His tag

Human Coagulation Factor II/Thrombin, CF - 2196-SE-200 from R&D Systems Category Protein Source Human plasma-derived

F2 protein (His tag) - 80R-3796 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

Prothrombin protein - 30C-CP3048U from Fitzgerald Category Protein Prices $226.80 Sizes 2 mg

Prothrombin (F2) (328-622, His-tag) - AR51483PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Prothrombin (F2) (328-622, His-tag) - AR51483PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Prothrombin (F2) - H00002147-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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