| Gene Symbol |
F2
|
| Entrez Gene |
2147
|
| Alt Symbol |
PT, RPRGL2, THPH1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coagulation factor II (thrombin)
|
| Other Description |
prepro-coagulation factor II|prothrombin|prothrombin B-chain|serine protease
|
| Swissprots |
Q53H06 B2R7F7 P00734 Q7Z7P3 Q4QZ40 Q53H04 Q9UCA1 B4E1A7 Q69EZ7
|
| Accessions |
AAB24476 AAC63054 AAL77436 AAM11680 CAD80258 CAL24231 EAW67977 EAW67978 EAW67979 P00734 AJ972449 CAJ01369 AK222775 BAD96495 AK222777 BAD96497 AK293326 BAG56844 AK303747 BAG64719 AK312965 BAG35804 AY344793 AAR08142 AY344794 AAR08143 BC051332 AAH51332 CB156997 DB183734 EU832664 ACE87755 EU832742 ACE87074 M33031 AAA60220 V00595 CAA23842 XR_428840 NM_000506 NP_000497
|
| Function |
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. {ECO:0000269|PubMed:2856554}.
|
| Subcellular Location |
Secreted, extracellular space.
|
| Tissue Specificity |
Expressed by the liver and secreted in plasma.
|
| Top Pathways |
Complement and coagulation cascades, Regulation of actin cytoskeleton, Neuroactive ligand-receptor interaction
|
