RSPO4
| Gene Symbol | RSPO4 |
|---|---|
| Entrez Gene | 343637 |
| Alt Symbol | C20orf182, CRISTIN4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | R-spondin 4 |
| Other Description | R-spondin family, member 4|R-spondin-4|hRspo4|roof plate-specific spondin-4 |
| Swissprots | Q9UGB2 A2A2I6 Q2I0M5 |
| Accessions | EAX10652 EAX10653 Q2I0M5 AK122609 BC156852 AAI56853 BQ185331 DQ355152 ABC75877 XM_011529232 XP_011527534 XM_011529233 XP_011527535 XR_937068 XR_937069 NM_001029871 NP_001025042 NM_001040007 NP_001035096 |
| Function | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076}. |
| Subcellular Location | Secreted {ECO:0000250}. |
RSPO4 overexpression lysate - LY422255 from Acris Antibodies
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R-Spondin 4 Overexpression Lysate (Native) - NBP2-08600 from Novus Biologicals
![Western Blot: RSPO4 Overexpression Lysate (Adult Normal) [NBP2-08600] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RSPO4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5449_RSPO4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08600-img0001.jpg)
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Panoply™ Human RSPO4 Knockdown Stable Cell Line - CSC-DC013658 from Creative biogene
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