RSPO4

Gene Symbol RSPO4
Entrez Gene 343637
Alt Symbol C20orf182, CRISTIN4
Species Human
Gene Type protein-coding
Description R-spondin 4
Other Description R-spondin family, member 4|R-spondin-4|hRspo4|roof plate-specific spondin-4
Swissprots Q9UGB2 A2A2I6 Q2I0M5
Accessions EAX10652 EAX10653 Q2I0M5 AK122609 BC156852 AAI56853 BQ185331 DQ355152 ABC75877 XM_011529232 XP_011527534 XM_011529233 XP_011527535 XR_937068 XR_937069 NM_001029871 NP_001025042 NM_001040007 NP_001035096
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076}.
Subcellular Location Secreted {ECO:0000250}.

RSPO4 Antibody Blocking Peptide - LS-E7942 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

RSPO4-Antibody-C-term-Blocking-peptide - BP5711b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Recombinant Human R-Spondin 4 - 4575-RS-025 from R&D Systems

Category Protein
Source Chinese Hamster Ovary cell line, CHO-derived, Met1-Pro234

Recombinant Human R-Spondin 4, CF - 4575-RS-025/CF from R&D Systems

Category Protein
Source Chinese Hamster Ovary cell line, CHO-derived, Met1-Pro234

Recombinant Human RSPO4 - RSPO4-1001H from Creative Biomart

Category Protein
Source Mammalian Cells
Species Human

Recombinant Human R-spondin-4(RSPO4) - CSB-YP644152HU CSB-EP644152HU CSB-BP644152HU CSB-MP644152HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Recombinant Human R-Spondin 4 Protein - 4575-RS from R&D Systems

Category Protein
Prices $329.00
Sizes 25 µg
Source Chinese Hamster Ovary cell line, CHO-derived Met1-Pro234
Species Human

Recombinant Human R-Spondin 4 Protein, CF - 4575-RS/CF from R&D Systems

Category Protein
Prices $329.00
Sizes 25 µg
Source Chinese Hamster Ovary cell line, CHO-derived Met1-Pro234
Species Human

R-Spondin 4 Recombinant Protein Antigen - NBP2-30540PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

RSPO4 Peptide, Human - M34GP13658H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

R-spondin-4 (RSPO4), Recombinant Protein - MBS1482872 from MyBioSource

Category Protein
Prices $965.00, $965.00, $1,190.00, $1,190.00, $1,450.00, $1,450.00, $1,915.00, $1,915.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

Recombinant Human R-Spondin 4 Protein - 4575-RS from Novus Biologicals

Category Protein
Prices $329.00
Sizes 25 µg
Species Human

Recombinant Mouse R-Spondin 4 Protein - 4106-RS from Novus Biologicals

Category Protein
Prices $329.00
Sizes 25 µg
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