RSPO4

Gene Symbol	RSPO4
Entrez Gene	343637
Alt Symbol	C20orf182, CRISTIN4
Species	Human
Gene Type	protein-coding
Description	R-spondin 4
Other Description	R-spondin family, member 4|R-spondin-4|hRspo4|roof plate-specific spondin-4
Swissprots	Q9UGB2 A2A2I6 Q2I0M5
Accessions	EAX10652 EAX10653 Q2I0M5 AK122609 BC156852 AAI56853 BQ185331 DQ355152 ABC75877 XM_011529232 XP_011527534 XM_011529233 XP_011527535 XR_937068 XR_937069 NM_001029871 NP_001025042 NM_001040007 NP_001035096
Function	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076}.
Subcellular Location	Secreted {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

R-Spondin4 (G-13) - sc-85856 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

R-Spondin4 (H-70) - sc-98333 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

R-Spondin4 (P-14) - sc-85857 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-RSPO4 antibody - ab98016 from Abcam Prices $242.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RSPO4 antibody - ab199892 from Abcam Host Rabbit Clonality Polyclonal

Anti-RSPO4 antibody [EPR9806(2)] - ab189515 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR9806(2)

Anti-RSPO4 antibody - C-terminal - ab175244 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RSPO4 Antibody (aa21-197) - LS-C75550 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-RSPO4 Antibody (C-Terminus, AP) - LS-C240279 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RSPO4 Antibody (C-Terminus, APC) - LS-C240280 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RSPO4 Antibody (C-Terminus, FITC) - LS-C240283 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RSPO4 Antibody (C-Terminus, PE) - LS-C240284 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RSPO4 Antibody (C-Terminus, Biotin) - LS-C240281 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RSPO4 Antibody (C-Terminus, Azide-free, HRP) - LS-C248057 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RSPO4 Antibody (C-Terminus) - LS-C324849 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RSPO4 Antibody (aa199-228) - LS-C162784 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

R-Spondin 4 Antibody (435203) - MAB4106 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Rat Clonality Monoclonal Clone 435203

R-Spondin 4 Antibody - AF4106 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

R-Spondin 4 Antibody - NBP2-30540 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ANTI-RSPO4 (C-TERM) antibody produced in rabbit - SAB1301084 from Sigma-Aldrich Prices $326.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RSPO4 antibody produced in rabbit - HPA048887 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RSPO4 Antibody - C-terminal region (OAAB03119) - OAAB03119 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

RSPO4-Antibody-C-term - AP5711b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

Mouse R-Spondin 4 Antibody - AF4106 from R&D Systems Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat

Mouse R-Spondin 4 Affinity Purified Polyclonal Ab, Goat IgG - AF4106-SP from R&D Systems Host Goat Clonality Polyclonal

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