RSPO4

Gene Symbol RSPO4
Entrez Gene 343637
Alt Symbol C20orf182, CRISTIN4
Species Human
Gene Type protein-coding
Description R-spondin 4
Other Description R-spondin family, member 4|R-spondin-4|hRspo4|roof plate-specific spondin-4
Swissprots Q9UGB2 A2A2I6 Q2I0M5
Accessions EAX10652 EAX10653 Q2I0M5 AK122609 BC156852 AAI56853 BQ185331 DQ355152 ABC75877 XM_011529232 XP_011527534 XM_011529233 XP_011527535 XR_937068 XR_937069 NM_001029871 NP_001025042 NM_001040007 NP_001035096
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076}.
Subcellular Location Secreted {ECO:0000250}.

R-Spondin4 CRISPR/Cas9 KO Plasmid (h) - sc-407886 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin4 HDR Plasmid (h) - sc-407886-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin4 Double Nickase Plasmid (h) - sc-407886-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin4 Double Nickase Plasmid (h2) - sc-407886-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin4 CRISPR Activation Plasmid (h) - sc-407886-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin4 CRISPR Activation Plasmid (h2) - sc-407886-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin4 Lentiviral Activation Particles (h) - sc-407886-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin4 Lentiviral Activation Particles (h2) - sc-407886-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin4 siRNA (h) - sc-76309 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

R-Spondin4 shRNA Plasmid (h) - sc-76309-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

R-Spondin4 shRNA (h) Lentiviral Particles - sc-76309-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN18721 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18721 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RSPO4 siRNA (Human) - CRJ7437 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

R-Spondin 4 RNAi - H00343637-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RSPO4 - MBS8219010 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RSPO4 (NM_001029871.3) - SHH400356 from Creative biogene

Category siRNA
Species Reactivities Human

Human RSPO4 siRNA - orb277938 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RSPO4 shRNA Plasmid (Human) - CHJ7437 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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