Tfam

Gene Symbol Tfam
Entrez Gene 83474
Alt Symbol Mttfa
Species Rat
Gene Type protein-coding
Description transcription factor A, mitochondrial
Other Description -
Swissprots Q91ZW1 Q9WTM7
Accessions AAF74765 EDL97257 EDL97258 EDL97259 Q91ZW1 AB014089 BAA77755 AF246196 AAG09777 AF377866 AAL12892 AJ312746 CAC84763 BC062022 AAH62022 FQ219683 NM_031326 NP_112616
Function Isoform Mitochondrial binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA (By similarity). Isoform Nuclear may also function as a transcriptional activator or may have a structural role in the compaction of nuclear DNA during spermatogenesis (By similarity). {ECO:0000250}.
Subcellular Location Isoform Mitochondrial: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}.
Tissue Specificity The mitochondrial isoform is widely expressed while the nuclear isoform is testis-specific.
Top Pathways Huntington's disease

Rat Tfam cDAN Clone(NM_031326.1) - CDFR012631 from Creative Biomart

Species Rat
Accession NM_031326.1

Rat Tfam ORF Clone(NM_031326.1) - CDCR379664 from Creative Biomart

Species Rat
Accession NM_031326.1

Rat TFAM ORF clone(NM_031326.1) - CDCG000025 from Creative Biomart

Species Rat
Accession NM_031326.1

Rat Tfam ORF Clone(NM_031326.1) - CDCR379664 from Creative biogene

Species Rat

Rat Tfam cDNA Clone(NM_031326.1) - CDFR012631 from Creative biogene

Species Rat
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