Tfam

Gene Symbol Tfam
Entrez Gene 83474
Alt Symbol Mttfa
Species Rat
Gene Type protein-coding
Description transcription factor A, mitochondrial
Other Description -
Swissprots Q91ZW1 Q9WTM7
Accessions AAF74765 EDL97257 EDL97258 EDL97259 Q91ZW1 AB014089 BAA77755 AF246196 AAG09777 AF377866 AAL12892 AJ312746 CAC84763 BC062022 AAH62022 FQ219683 NM_031326 NP_112616
Function Isoform Mitochondrial binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA (By similarity). Isoform Nuclear may also function as a transcriptional activator or may have a structural role in the compaction of nuclear DNA during spermatogenesis (By similarity). {ECO:0000250}.
Subcellular Location Isoform Mitochondrial: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}.
Tissue Specificity The mitochondrial isoform is widely expressed while the nuclear isoform is testis-specific.
Top Pathways Huntington's disease

mtTFA siRNA (r) - sc-156067 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Rat

mtTFA shRNA Plasmid (r) - sc-156067-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Rat

CompoZr® Knockout ZFN Kit - CKOZFN64037 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND64037 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TFAM siRNA (Rat) - CRR2416 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

TFAM - MBS829615 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

shRNA set against Rat TFAM (NM_031326.1) - SHH426080 from Creative biogene

Category siRNA
Species Reactivities Rat

shRNA set against Rat Tfam(NM_031326.1) - SHL066456 from Creative biogene

Category siRNA
Species Reactivities Rat

TFAM shRNA Plasmid (Rat) - CHR2416 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Rat

TFAM miRNA 3'UTR clone - MiUTR1R-07976 from Creative biogene

Species Reactivities Rat
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